Anti-human Immunodeficiency Virus-1 Constituents of the Bark of Poncirus trifoliata

被引：18
|
作者：
Feng, Tao [3 ,4 ]
Wang, Rui-Rui [1 ,2 ]
Cai, Xiang-Hai [4 ]
Zheng, Yong-Tang [1 ,2 ]
Luo, Xiao-Dong [4 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Zool, Key Lab Anim Models & Human Dis Mech, Kunming 650223, Peoples R China
[2] Chinese Acad Sci, Kunming Inst Zool, Lab Mol Immunopharmacol, Kunming 650223, Peoples R China
[3] Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
[4] Chinese Acad Sci, State Key Lab Phytochem & Plant Resources W China, Kunming Inst Bot, Kunming 650204, Peoples R China
来源：
CHEMICAL & PHARMACEUTICAL BULLETIN | 2010年 / 58卷 / 07期
关键词：
Poncirus trifoliata; chemical constituent; prenylated flavonoid; anti-human immunodeficiency virus-1 activity; CITRUS BITTER PRINCIPLES; CHEMICAL-CONSTITUENTS; BINARY COUMARINS; ROOT BARK; FLAVONOIDS; FRUITS; PLANTS;
D O I：
10.1248/cpb.58.971
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A total of 36 compounds (1-36) were obtained from the stem bark of Poncirus trifoliata including three new prenylated flavonoids, (-)-5,4'-dihydroxy-7,8-[(3 '',4 ''-cis-dihydroxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (1), (-)-5,4'-dihydroxy-7,8-[(3 ''-hydroxy-4 ''-one)-2 '',2 ''-dimethylpyrano]-flavone (2), and (-)-5,4'-dihydroxy-7,8-[(cis-3 ''-hydroxy-4 ''-ethoxy-3 '',4 ''-dihydro)-2 '',2 ''-dimethylpyrano]-flavone (3). The new structures were elucidated by means of spectroscopic methods. Compounds 1-20 were evaluated for their anti-human immunodeficiency virus-1 (HIV-1) activity, in which 2 showed significant anti-HIV-1 activity with high therapeutic index (T1) of 143.65.
引用
收藏
页码：971 / 975
页数：5
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