Primary Epstein-Barr Virus Infection With Marked Cholestasis, Warm Autoimmune Hemolytic Anemia, and Pancytopenia

被引：0
|
作者：
Kazi, Aamir S. [1 ]
Hart, Aaron A. [2 ]
Rajakumar, Priya [3 ]
Janardhan, Sujit J. [4 ]
Dehghan-Paz, Irene [3 ]
Rhee, Yoona [1 ]
机构：
[1] Rush Univ, Div Infect Dis, Med Ctr, Suite 143,600 South Paulina St, Chicago, IL 60612 USA
[2] Rush Univ, Div Internal Med, Med Ctr, Chicago, IL 60612 USA
[3] Rush Univ, Div Hematol & Oncol, Med Ctr, Chicago, IL 60612 USA
[4] Rush Univ, Div Gastroenterol & Hepatol, Med Ctr, Chicago, IL 60612 USA
来源：
INFECTIOUS DISEASES IN CLINICAL PRACTICE | 2021年 / 29卷 / 03期
关键词：
Epstein-Barr virus; cholestatic hepatitis; hemolytic anemia; pancytopenia;
D O I：
10.1097/IPC.0000000000000945
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Primary Epstein-Barr virus (EBV) infection may rarely present with cholestatic hepatitis or hemolytic anemia. We share a case of EBV-associated infectious mononucleosis presenting with a unique triad of findings comprising cholestatic hepatitis with marked hyperbilirubinemia, warm autoimmune hemolytic anemia, and pancytopenia. Early diagnostic challenges included negative Monospot heterophile testing. Additional testing revealed EBV serologies consistent with acute primary infection, EBV viremia and bone marrow biopsy showing EBV-encoded RNA-positive cells. A tapered prednisone course was administered for warm autoimmune hemolytic anemia. Improvement in symptoms and laboratory findings occurred over 3 weeks.
引用
收藏
页码：e177 / e178
页数：2
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