Botulinum neurotoxin B-host receptor recognition: it takes two receptors to tango

被引：21
|
作者：
Baldwin, Michael R.
Kim, Jung-Ja P.
Barbieri, Joseph T.
机构：
[1] Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USA
[2] Med Coll Wisconsin, Dept Biochem, Milwaukee, WI 53226 USA
来源：
NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2007年 / 14卷 / 01期
关键词：
D O I：
10.1038/nsmb0107-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Two independent crystal structure analyses have resolved the detailed interactions between botulinum neurotoxin serotype B and its neuronal receptor, synaptotagmin. The studies show how the toxin binds synaptotagmin and, along with previously determined interactions with the ganglioside G(T1b), a coreceptor, explain the toxin's extreme toxicity and tropism for neurons.
引用
收藏
页码：9 / 10
页数：3
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