Highly efficient synthesis of chiral quaternary 3-aminooxindoles promoted by zinc(II) chloride via Et2Zn-catalysed addition of Grignard reagents to isaltin-derived N-tert-butanesulfinyl ketimines

被引：3

作者：

Yang, Shiwei ^{[1
,2
]}

Bian, Guangling ^{[1
]}

Chen, Zhongxiang ^{[1
]}

Xia, Xiaohan ^{[1
]}

Zhou, Mi ^{[1
]}

Cui, Caiyan ^{[1
]}

Song, Ling ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Coal Ethylene Glycol & Its Related Techno, Fuzhou 350002, Fujian, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

RSC ADVANCES | 2017年 / 7卷 / 61期

关键词：

ASYMMETRIC-SYNTHESIS; DIASTEREOSELECTIVE ADDITION; SULFINYL KETIMINES; AMINO-ACIDS; BETA-AMINO; KETONES; IMINES; ALKYLATION; INDOLES; CARBON;

D O I：

10.1039/c7ra07692d

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A highly efficient and practical approach to chiral quaternary 3-aminooxindoles was developed via Et2Zn catalyzed diastereoselective addition of Grignard reagents to isaltin-derived N-tert-butanesulfinyl ketimines giving good to excellent yields and diastereoselectivities with broad substrates and reagent scopes promoted by zinc(II) chloride.

引用

页码：38216 / 38219

页数：4