Aquaporins in tumor growth and angiogenesis

被引：91
|
作者：
Nico, Beatrice [1 ]
Ribatti, Domenico [1 ]
机构：
[1] Univ Bari, Sch Med, Dept Human Anat & Histol, I-70124 Bari, Italy
来源：
CANCER LETTERS | 2010年 / 294卷 / 02期
关键词：
Angiogenesis; Aquaporins; Metastastis; Tumor growth; HUMAN BRAIN-TUMORS; EMBRYO CHORIOALLANTOIC MEMBRANE; WATER CHANNEL; COLORECTAL CARCINOGENESIS; GENE DISRUPTION; CELL-MIGRATION; EXPRESSION; EDEMA; CANCER; AQP5;
D O I：
10.1016/j.canlet.2010.02.005
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The aquaporins (AQPs) are a family of transmembrane water channel proteins widely distributed and play a major role in transcellular and transepithelial water movement. Moreover, recent evidence indicates that AQPs may be involved in cell migration and angiogenesis. This review article summarizes literature data concerning the involvement of AQPs in tumor growth, angiogenesis and metastatic process and suggest a potential therapeutic approach by antagonizing their biological activity. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：135 / 138
页数：4
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