The Rotavirus Interferon Antagonist NSP1: Many Targets, Many Questions

被引：28
|
作者：
Arnold, Michelle M. [1 ]
机构：
[1] Louisiana State Univ, Hlth Sci Ctr, Ctr Mol & Tumor Virol, Dept Microbiol & Immunol, Shreveport, LA 71105 USA
来源：
JOURNAL OF VIROLOGY | 2016年 / 90卷 / 11期
关键词：
INNATE IMMUNE-RESPONSE; REGULATORY FACTOR-3; REPLICATION; DEGRADATION;
D O I：
10.1128/JVI.03068-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Rotavirus is a leading cause of death due to diarrhea among young children across the globe. Despite the limited coding capacity that is characteristic of RNA viruses, rotavirus dedicates substantial resources to avoiding the host innate immune response. Among these strategies is use of the interferon antagonist protein NSP1, which targets cellular proteins required for interferon production to be degraded by the proteasome. Although numerous cellular targets have been described, there remain many questions about the mechanism of NSP1 activity and its role in promoting replication in specific host species.
引用
收藏
页码：5212 / 5215
页数：4
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