MicroRNA as Potential Biomarkers of Platelet Function on Antiplatelet Therapy: A Review

被引：29

作者：

Czajka, Pamela ^{[1
]}

Fitas, Alex ^{[1
]}

Jakubik, Daniel ^{[1
]}

Eyileten, Ceren ^{[1
]}

Gasecka, Aleksandra ^{[2
]}

Wicik, Zofia ^{[1
,3
]}

Siller-Matula, Jolanta M. ^{[1
,4
]}

Filipiak, Krzysztof J. ^{[2
]}

Postula, Marek ^{[1
]}

机构：

[1] Med Univ Warsaw, Ctr Preclin Res & Technol, Dept Expt & Clin Pharmacol, Warsaw, Poland

[2] Med Univ Warsaw, Chair & Dept Cardiol 1, Warsaw, Poland

[3] Univ Fed ABC, Ctr Matemat Comp & Cognicao, Sao Paulo, Brazil

[4] Med Univ Vienna, Dept Cardiol, Vienna, Austria

来源：

FRONTIERS IN PHYSIOLOGY | 2021年 / 12卷

关键词：

miRNA; platelets; platelet reactivity; antiplatelet therapy; biomarker; PERCUTANEOUS CORONARY INTERVENTION; P2Y(12) RECEPTOR; ARTERY-DISEASE; CLOPIDOGREL; REACTIVITY; ASPIRIN; INHIBITION;

D O I：

10.3389/fphys.2021.652579

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

MicroRNAs (miRNAs) are small, non-coding RNAs, able to regulate cellular functions by specific gene modifications. Platelets are the major source for circulating miRNAs, with significant regulatory potential on cardiovascular pathophysiology. MiRNAs have been shown to modify the expression of platelet proteins influencing platelet reactivity. Circulating miRNAs can be determined from plasma, serum, or whole blood, and they can be used as diagnostic and prognostic biomarkers of platelet reactivity during antiplatelet therapy as well as novel therapeutic targets in cardiovascular diseases (CVDs). Herein, we review diagnostic and prognostic value of miRNAs levels related to platelet reactivity based on human studies, presenting its interindividual variability as well as the substantial role of genetics. Furthermore, we discuss antiplatelet treatment in the context of miRNAs alterations related to pathways associated with drug response.

引用

页数：16

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