Acquisition of siderophores in Gram-negative bacteria

被引：276
|
作者：
Faraldo-Gómez, JD
Sansom, MSP
机构：
[1] Cornell Univ, Weill Med Coll, Dept Biochem, New York, NY 10021 USA
[2] Univ Oxford, Dept Biochem, Lab Mol Biophys, Oxford OX1 3QU, England
来源：
NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 02期
关键词：
D O I：
10.1038/nrm1015
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The outer membrane of Gram-negative bacteria constitutes a permeability barrier that protects the cell from exterior hazards, but also complicates the uptake of nutrients. In the case of iron, the challenge is even greater, because of the scarcity of this indispensable element in the cell's surroundings. To solve this dilemma, bacteria have evolved sophisticated mechanisms whereby the concerted actions of receptor, transporter and energy-transducing proteins ensure that there is a sufficient supply of iron-containing compounds, such as siderophores.
引用
收藏
页码：105 / 116
页数：12
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