Automated Electrochemical Analyzer as a New Tool for Detection of Thiols

被引:0
|
作者
Adam, Vojtech [1 ]
Fabrik, Ivo [1 ]
Kohoutkova, Veronika [2 ]
Babula, Petr [2 ]
Hubalek, Jaromir [3 ]
Vrba, Radimir [3 ]
Trnkova, Libuse [4 ,5 ]
Kizek, Rene [1 ]
机构
[1] Mendel Univ Brno, Dept Chem & Biochem, CZ-61300 Brno, Czech Republic
[2] Univ Vet & Pharmaceut Sci, Fac Pharm, Dept Nat Drugs, CZ-61242 Brno, Czech Republic
[3] Brno Univ Technol, Fac Elect Engn & Commun, Dept Microelect, CZ-60200 Brno, Czech Republic
[4] Masaryk Univ, Dept Chem, CZ-61137 Brno, Czech Republic
[5] Masaryk Univ, Fac Sci, Res Ctr Environm Chem & Ecotoxicol, CZ-61137 Brno, Czech Republic
来源
关键词
Automated Electrochemical Detection; Drugs; Tumour Disease Markers; Proteins; Metallothioneins; POSITRON-EMISSION-TOMOGRAPHY; CARBON-PASTE ELECTRODE; ADSORPTIVE STRIPPING VOLTAMMETRY; ANTILEUKEMIA DRUG GLIVEC; DIFFERENTIAL-PULSE VOLTAMMETRY; MERCURY DROP ELECTRODE; HEAVY-METAL IONS; BIOSYNTHETIC POLYNUCLEOTIDES; CYCLIC VOLTAMMETRY; BRDICKA REACTION;
D O I
暂无
中图分类号
O646 [电化学、电解、磁化学];
学科分类号
081704 ;
摘要
Stationary electrochemical analysers are advantageous tools for detection of electroactive species. There advantages are low cost, sensitivity and repeatability. However, non-automated injection of samples belongs to their main disadvantages. We aim our attention to present a new electrochemical tool connected with unique autosampler enabling us to inject units of mu l, which is essential in for detection of biological samples. The analyser can be used for detection of peptides, proteins, nucleic acids, drugs. Moreover, the highest sensitivity has for thiols. The recent advances in the field of electrochemistry of mentioned biologically active compounds, mainly metallothionein, are also discussed.
引用
收藏
页码:429 / 447
页数:19
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