Malignant ovarian tumor composed of endometrioid adenocarcinoma, clear cell adenocarcinoma, squamous cell carcinoma, yolk sac tumor and immature teratoma with prominent neuroectodermal and rhabdomyosarcomatous differentiation: A case study

Background. Cases of malignant ovarian tumor composed of mullerian-type epithelial tumor and malignant germ cell tumor are extremely rare. Case. We herein report the case of a 34-year-old woman with an ovarian tumor which was composed of endometrioid adenocarcinoma (EAC), clear cell adenocarcinoma (CCC), squamous cell carcinoma, yolk sac tumor (YST) and immature teratoma with prominent neuroectodermal and rhabdomyosarcomatous differentiation. Even after systemic chemotherapy, this intriguing tumor recurred again and again, which is in contrast to pure germ cell tumor which is known to be sensitive to chemotherapy. Conclusion. No previous cases with an identical composition have been found in the literature. Correct diagnosis of this complex and aggressive tumor is paramount. (C) 2007 Elsevier Inc. All rights reserved.