Acoustic monitoring of a fluidized bed coating process

被引:31
|
作者
Naelapaa, Kaisa
Veski, Peep
Pedersen, Joan G.
Anov, Dan
Jorgensen, Pia
Kristensen, Henning G.
Bertelsen, Poul
机构
[1] Nycomed, Int Pharmaceut Affairs, DK-4000 Roskilde, Denmark
[2] Univ Tartu, Dept Pharm, EE-50411 Tartu, Estonia
[3] Danish Technol Inst, DK-6000 Kolding, Denmark
[4] Danish Univ Pharmaceut Sci, Dept Pharmaceut & Anal Chem, DK-2100 Copenhagen, Denmark
关键词
process monitoring; passive acoustic emission; top spray coating; ethylcellulose;
D O I
10.1016/j.ijpharm.2006.09.036
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The aim of the study was to investigate the potential of acoustic monitoring of a production scale fluidized bed coating process. The correlation between sensor signals and the estimated amount of film applied and percentage release, respectively, were investigated in coating potassium chloride (KCl) crystals with ethylcellulose (EC). Vibrations were measured with two different types of accelerometers. Different positions for placing the accelerometers and two different product containers were included in the study. Top spray coating of KCl was chosen as a 'worst case' scenario from a coating point perspective. The acoustic monitoring has the potential of summarising the commonly used means to monitor the coating process. The best partial least squares (PLS) regressions, obtained by the high frequency accelerometer, showed for the release a correlation coefficient of 0.92 and a root mean square error of prediction (RMSEP) of 5.84% (31-82.8%), and for the estimated amount of film applied a correlation coefficient of 0.95 and RMSEP of 0.52% (0.6-6%). The results of the preliminary investigation are considered promising. There is however a need for further investigations on sampling procedures and product characterisation before a final conclusion on the applicability of acoustic monitoring can be made. (c) 2006 Elsevier B.V. All rights reserved.
引用
收藏
页码:90 / 97
页数:8
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