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Sichuan Univ, W China Hosp, Dept Med Genet,Div Human Morbid Genom, Key State Lab Biotherapy Human Dis, Chengdu 610041, Peoples R China Sichuan Univ, W China Hosp, Dept Med Genet,Div Human Morbid Genom, Key State Lab Biotherapy Human Dis, Chengdu 610041, Peoples R China