Tyrphostin A9 improves blastocyst development in porcine embryos through induction of dynamin-related protein 1-dependent mitochondrial fission

被引：8
|
作者：
Ahn, Jae-Hyun [1 ]
Park, Hyo-Jin [1 ]
Kim, Jin-Woo [1 ]
Park, Jae-Young [1 ]
Park, Soo-Yong [1 ]
Yang, Seul-Gi [1 ]
Kim, Chang-Hyun [2 ]
Yoon, Seung-Bin [3 ,4 ]
Kim, Sun-Uk [3 ,4 ]
Chang, Kyu-Tae [3 ,4 ]
Koo, Deog-Bon [1 ]
机构：
[1] Daegu Univ, Dept Biotechnol, Coll Engn, 201 Daegudae Ro, Gyongsan 38453, Gyeongbuk, South Korea
[2] Dongguk Univ, Coll Med, Goyang 10326, South Korea
[3] Korea Res Inst Biosci & Biotechnol, Futurist Anim Resource & Res Ctr, Ochang 28116, Chungbuk, South Korea
[4] Korea Res Inst Biosci & Biotechnol, Natl Primate Res Ctr, Ochang 28116, Chungbuk, South Korea
来源：
MITOCHONDRION | 2017年 / 35卷
关键词：
Tyrphostin A9 (TA9); Mitochondrial fission; Drp1; Mitochondrial function; Porcine embryo; IN-VITRO; FUSION; APOPTOSIS; OOCYTE; MOUSE; CELLS; INHIBITOR; BALANCE;
D O I：
10.1016/j.mito.2017.05.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Mitochondrial dynamics are associated with the development of porcine embryos. However, little is known about the effects of mitochondrial dynamics-related genes (Drp1 and pDrpl-Ser616) on early porcine embryo development. Here, we investigated the effect of Drpl-dependent mitochondrial fission signaling on the development of porcine embryos using the mitochondrial fission inducer, tyrphostin A9 (TA9). We determined that TA9 (1 mu M) treated embryos were increased the mitochondrial functions, blastocyst development rate and quality, as well as decreased mitochondria-specific superoxide and mitochondrial apoptosis. Thus, TA9-induced appropriate mitochondrial fission improved the developmental competence via maintenance of a balance in mitochondrial dynamics in porcine embryo.
引用
收藏
页码：80 / 86
页数：7
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