DMAP-catalyzed cyanation of aldehydes and ketones with ethyl cyanoformate

被引：29
|
作者：
Aoki, Shohei [2 ]
Kotani, Shunsuke [1 ]
Sugiura, Masaharu [2 ]
Nakajima, Makoto [2 ]
机构：
[1] Kumamoto Univ, Prior Org Innovat & Excellence, Kumamoto 8620973, Japan
[2] Kumamoto Univ, Grad Sch Pharmaceut Sci, Kumamoto 8620973, Japan
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 27期
关键词：
O-METHOXYCARBONYL CYANOHYDRIN; DOUBLE-ACTIVATION METHOD; ENANTIOSELECTIVE CYANOSILYLATION; LEWIS-ACID; ASYMMETRIC CYANOSILYLATION; TRIMETHYLSILYL CYANIDE; ALPHA; BETA-UNSATURATED ALDEHYDES; PROTECTIVE GROUP; N-OXIDE; CYANOFORMYLATION;
D O I：
10.1016/j.tetlet.2010.04.123
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The cyanation of carbonyl compounds with ethyl cyanoformate is catalyzed by 4-dimethylaminopyridine (DMAP) to afford the corresponding cyanohydrin carbonates in excellent yields. The system provides a convenient method for cyanation of carbonyl compounds without using metal catalysts or solvents. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码：3547 / 3549
页数：3
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