Application of micellar electrokinetic chromatography for analyzing antiviral drugs in pharmaceutical semisolid formulations

被引：11
|
作者：
Neubert, RHH [1 ]
Mrestani, Y [1 ]
Schwarz, M [1 ]
Colin, B [1 ]
机构：
[1] Univ Halle Wittenberg, Inst Pharmaceut & Biopharmaceut, D-06120 Halle, Germany
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 1998年 / 16卷 / 05期
关键词：
MEKC; analysis of aciclovir and brivudin; semisolid formulations; vaseline; hydrogel; drug content;
D O I：
10.1016/S0731-7085(97)00130-1
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
The application of micellar electrokinetic chromatography (MEKC) to the determination of the antiviral drugs brivudin (BV) and aciclovir (AC) in pharmaceutical semisolid formulations was studied. A method was developed for separating AC and BV both from hydrophilic and from lipophilic semisolid formulations and for the rapid determination of BV and AC using MEKC. The detection limit, the effective mobility and the relative standard deviation of the migration times and of the peak areas were determined. (C) 1998 Elsevier Science B.V.
引用
收藏
页码：893 / 897
页数：5
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