An unusually high level of quinolone resistance associated with type II topoisomerase mutations in quinolone resistance-determining regions of Aeromonas caviae isolated from diarrhoeal patients

被引：18
|
作者：
Sinha, S
Chattopadhyay, S
Bhattacharya, SK
Nair, GB
Ramamurthy, T [1 ]
机构：
[1] Natl Inst Cholera & Enter Dis, Kolkata 700010, W Bengal, India
[2] ICDDR B, Dhaka 1212, Bangladesh
来源：
RESEARCH IN MICROBIOLOGY | 2004年 / 155卷 / 10期
关键词：
Aeromonas caviae; quinolones; resistance; mutations;
D O I：
10.1016/j.resmic.2004.06.008
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
We examined 158 strains belonging to different Aeromonas species isolated from hospitalized acute diarrhoea cases for susceptibility to quinolones. Compared to other species, a high percentage of the A. caviae strains were resistant to ciprofloxacin and norfloxacin. Based on MIC values, 6 A. caviae strains were selected and the nucleotide sequences for the quinolone-resistant-determining regions (QRDRs) of gyrA, gyrB and parC genes were analysed. In resistant strains, double mutations (Ser(83)-->Ile and Asp(87)-->Asn) and a single mutation (Ser(80)-->Ile) were detected in the QRDR of gyrA and parC, respectively. (C) 2004 Elsevier SAS. All rights reserved.
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收藏
页码：827 / 829
页数：3
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