Synthesis and in vitro antiproliferative activity of diphenyl(sulphonylpiperidin-4-yl)methanol derivatives

被引：14

作者：

Prasad, S. B. Benaka ^{[1
]}

Vinaya, K. ^{[1
]}

Kumar, C. S. Ananda ^{[1
]}

Swarup, Sanjay ^{[2
]}

Rangappa, K. S. ^{[1
]}

机构：

[1] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India

[2] Natl Univ Singapore, Dept Biol Sci, Singapore 117548, Singapore

来源：

MEDICINAL CHEMISTRY RESEARCH | 2010年 / 19卷 / 03期

关键词：

Diphenyl(pyridin-4-yl)methanol; Sulfonyl chloride; MTT assay; Antiproliferative activity; Cancer therapy; Cell proliferation; EFFICACY; AGENTS;

D O I：

10.1007/s00044-009-9186-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel diphenyl(piperidin-4-yl)methanol derivatives 10(a-n) were synthesized and characterized by H-1 NMR, LC/MS, FTIR, and elemental analyses. All the synthesized compounds were evaluated for cell proliferation by MTT assay. The antiproliferative effects of the synthesized compounds were tested against viable human skin fibroblast cell line and carcinoma cell lines, namely HeLa cells, HT-29 cells, MCF-7 cells, and HepG-2 cells in comparing the positive and negative control. Among the synthesized compounds, (10b) and (10g) have been identified as potent antiproliferative agents.

引用

页码：220 / 235

页数：16

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