Testing the extent of sequence similarity among viroids, satellite RNAs, and hepatitis delta virus

被引:14
|
作者
Jenkins, GM
Woelk, CH
Rambaut, A
Holmes, EC
机构
[1] Univ Oxford, Dept Zool, Wellcome Trust Ctr Epidemiol Infect Dis, Oxford OX1 3PS, England
[2] Univ Oxford, Dept Zool, Oxford OX1 3PS, England
关键词
viroids; satellite RNAs; hepatitis delta virus; Monte Carlo simulation; sequence similarity;
D O I
10.1007/s002399910011
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A Monte Carlo method was used to test the extent of sequence similarity among viroids, satellite RNAs, and hepatitis delta virus. This analysis revealed that there is insufficient sequence similarity among these pathogens to support the hypothesis that they have a common evolutionary origin. Furthermore, while definite patterns of sequence similarity were observed among some viroids, there was a clear lack of overall similarity, indicating that a monophyletic origin for even this group cannot be reliably supported from sequence data alone.
引用
收藏
页码:98 / 102
页数:5
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