Valproic Acid Treatment Enhances Hematopoietic Stem and Progenitor Cell Multipotency Ex Vivo for Enhanced Long-Term Engraftment of Gene-Modified Cells

被引:0
|
作者
Conway, Anthony [1 ]
Boyko, Alisa [1 ]
Hardin, Jeremy [1 ]
Holmes, Michael C. [1 ]
Cost, Gregory J. [1 ]
机构
[1] Sangamo BioSci, Richmond, CA USA
关键词
D O I
10.1016/S1525-0016(16)33241-5
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
432
引用
收藏
页码:S171 / S171
页数:1
相关论文
共 50 条
  • [1] ENABLING EFFICIENT EX VIVO EXPANSION OF LONG-TERM HUMAN HEMATOPOIETIC STEM AND PROGENITOR CELLS FOR CELL THERAPY
    Sei, J.
    Becker, A. Harris
    Kaur, N.
    Vemuri, M.
    Kuninger, D.
    CYTOTHERAPY, 2018, 20 (05) : S122 - S122
  • [2] UM171 enhances fitness and engraftment of gene-modified hematopoietic stem cells from patients with sickle cell disease
    Liu, Boya
    Klatt, Denise
    Zhou, Yu
    Manis, John P.
    Sauvageau, Guy
    Pellin, Danilo
    Brendel, Christian
    Williams, David A.
    BLOOD ADVANCES, 2024, 8 (22) : 5885 - 5895
  • [3] LONG-TERM EX VIVO EXPANSION OF FUNCTIONAL HEMATOPOIETIC STEM CELLS
    Wilkinson, Adam
    Ishida, Reiko
    Kikuchi, Misako
    Sudo, Kazuhiro
    Morita, Maiko
    Crisostomo, Ralph Valentine
    Yamamoto, Ryo
    Loh, Kyle
    Nakamura, Yukio
    Watanabe, Motoo
    Nakauchi, Hiromitsu
    Yamazaki, Satoshi
    EXPERIMENTAL HEMATOLOGY, 2019, 76 : S42 - S42
  • [4] Long-term ex vivo expansion of mouse hematopoietic stem cells
    Wilkinson, Adam C.
    Ishida, Reiko
    Nakauchi, Hiromitsu
    Yamazaki, Satoshi
    NATURE PROTOCOLS, 2020, 15 (02) : 628 - 648
  • [5] Long-term ex vivo expansion of mouse hematopoietic stem cells
    Adam C. Wilkinson
    Reiko Ishida
    Hiromitsu Nakauchi
    Satoshi Yamazaki
    Nature Protocols, 2020, 15 : 628 - 648
  • [6] Long-Term Engraftment and In Vivo Selection of Hematopoietic Stem/Progenitor Cells Generated By Vascular Niche Induction of Induced Pluripotent Stem Cells
    Gori, Jennifer L.
    Butler, Jason M.
    Chandrasekaran, Devikha
    Poulos, Michael G.
    Beard, Brian C.
    Ginsberg, Michael
    Nolan, Daniel J.
    Elemento, Olivier
    Adair, Jennifer E.
    Rafii, Shahin
    Kiem, Hans-Peter
    MOLECULAR THERAPY, 2014, 22 : S14 - S14
  • [7] Rapamycin Enhances Long-Term Hematopoietic Reconstitution of Ex Vivo Expanded Mouse Hematopoietic Stem Cells by Inhibiting Senescence
    Luo, Yi
    Li, Lei
    Zou, Ping
    Wang, Jie
    Shao, Lijian
    Zhou, Daohong
    Liu, Lingbo
    TRANSPLANTATION, 2014, 97 (01) : 20 - 29
  • [8] Engraftment of Gene-Modified Autologous Hematopoietic Stem/Progenitor Cells in the Nonhuman Primate After Expansion on Human Vascular Endothelium
    Gori, Jennifer L.
    Butler, Jason M.
    Ginsberg, Michael
    Nolan, Daniel J.
    Adair, Jennifer E.
    Rafii, Shahin
    Kiem, Hans-Peter
    MOLECULAR THERAPY, 2014, 22 : S203 - S203
  • [9] An improved medium formulation for efficient ex vivo gene editing, expansion and engraftment of hematopoietic stem and progenitor cells
    Rai, Rajeev
    Naseem, Asma
    Vetharoy, Winston
    Steinberg, Zohar
    Thrasher, Adrian J.
    Santilli, Giorgia
    Cavazza, Alessia
    MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT, 2023, 29 : 58 - 69
  • [10] Ex vivo pre-conditioning of hematopoietic stem/progenitor cells impairs long-term hematopoietic repopulation after transplantation
    Lee, Hakmo
    Park, Ho Seon
    Oh, Ju Eun
    Park, Jongwoo
    Chung, Sung Soo
    Park, Kyong Soo
    Jung, Hye Seung
    JOURNAL OF IMMUNOLOGY, 2014, 192