Bioactive marine alkaloids

被引：115
|
作者：
Urban, S
Hickford, SJH
Blunt, JW
Munro, MHG [1 ]
机构：
[1] Univ Canterbury, Dept Chem, Christchurch 1, New Zealand
[2] Natl Inst Water & Atmospher Res Ltd, Auckland, New Zealand
来源：
CURRENT ORGANIC CHEMISTRY | 2000年 / 4卷 / 07期
关键词：
D O I：
10.2174/1385272003376085
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The structures, origins, biogenesis, synthesis and bioactivity of a selection of N-heterocyclic marine alkaloids are reviewed. The emphasis is on compounds poised as potential anticancer drugs: lamellarins (pyrroles), cephalostatins/ritterazines (pyrazines) and ecteinascidins (isoquinolines). Also discussed are examples of bioactive marine alkaloids that have emerged as novel leads. These include manzamines (beta-carbolines), variolins (pyridopyrrolopyrimidines) and the pyrroloquinoline family. This review emphasises the role of marine alkaloids as an important source of leads for drug discovery.
引用
收藏
页码：765 / 807
页数：43
相关论文
共 50 条
  • [1] BIOACTIVE MARINE ALKALOIDS
    BHAKUNI, DS
    JOURNAL OF THE INDIAN CHEMICAL SOCIETY, 1994, 71 (6-8) : 329 - 340
  • [2] Studies in bioactive marine alkaloids
    Kuramoto, M
    Arimoto, H
    Uemura, D
    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2003, 61 (11) : 1099 - 1105
  • [3] Structures and functions of marine bioactive alkaloids
    Kuramoto, M
    Chou, T
    Uemura, D
    JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 1999, 57 (02) : 105 - 115
  • [4] Total synthesis of the bioactive marine alkaloids.
    Poullennec, KG
    Romo, D
    ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2002, 224 : U180 - U180
  • [5] The pterocellins, bioactive alkaloids from the marine bryozoan Pterocella vesiculosa
    M.R Prinsep
    B Yao
    B.K Nicholson
    D.P Gordon
    Phytochemistry Reviews, 2004, 3 (3) : 325 - 331
  • [6] Bioactive Guanidine Alkaloids from Two Caribbean Marine Sponges
    Laville, Remi
    Thomas, Olivier P.
    Berrue, Fabrice
    Marquez, Diana
    Vacelet, Jean
    Amade, Philippe
    JOURNAL OF NATURAL PRODUCTS, 2009, 72 (09): : 1589 - 1594
  • [7] Bioactive sulfated sesterterpene alkaloids from the marine sponge Fasciospongia sp
    Yao, G. M.
    Kondratyuk, T. P.
    Pezzuto, J. M.
    Chang, L. C.
    PLANTA MEDICA, 2008, 74 (09) : 1065 - 1066
  • [8] Total synthesis of bioactive tricyclic marine alkaloids, lepadiformine and related compounds
    Kibayashi, C
    Aoyagi, S
    Abe, H
    BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 2003, 76 (11) : 2059 - 2074
  • [9] Recent research progresses on lamellarins and analogous alkaloids of bioactive marine mollusc
    Yang, G
    Wang, AL
    Chen, HL
    You, YC
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2005, 25 (06) : 641 - 653
  • [10] The pterocellins, novel bioactive alkaloids from the marine bryozoan Pterocella vesiculosa
    Yao, B
    Prinsep, MR
    Nicholson, BK
    Gordon, DP
    JOURNAL OF NATURAL PRODUCTS, 2003, 66 (08): : 1074 - 1077
12345