Gene therapy to protect haematopoietic cells from cytotoxic cancer drugs

被引：65
|
作者：
Sorrentino, BR [1 ]
机构：
[1] St Jude Childrens Res Hosp, Dept Hematol Oncol, Div Expt Hematol, Memphis, TN 38105 USA
来源：
NATURE REVIEWS CANCER | 2002年 / 2卷 / 06期
关键词：
D O I：
10.1038/nrc823
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
One of the most important complications of cancer chemotherapy is the toxic effect that the drugs have on normal tissues - particularly the bone marrow. Several gene-therapy vectors have been developed with the aim of expressing drug-resistance genes specifically in bone-marrow stem cells, so protecting them from chemotherapeutics. The feasibility of this approach has been established in animal model systems, and recent advances in the design of gene-therapy vectors offer promise for future clinical applications.
引用
收藏
页码：431 / 441
页数：11
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