Ectonucleotidase Inhibitory and Redox Activity of Imidazole-Based Organic Salts and Ionic Liquids

被引：3

作者：

Boldescu, Veaceslav ^{[1
]}

Sucman, Natalia ^{[1
]}

Hassan, Sidra ^{[2
]}

Iqbal, Jamshed ^{[2
]}

Neamtu, Mariana ^{[3
]}

Lecka, Joanna ^{[4
,5
]}

Sevigny, Jean ^{[4
,5
]}

Prodius, Denis ^{[6
,7
,8
]}

Macaev, Fliur ^{[1
]}

机构：

[1] Inst Chem, Lab Organ Synth & Biopharmaceut, 3 Acad Str, Kishinev 2028, Moldova

[2] COMSATS Inst Informat Technol, Dept Pharmaceut Sci, Abbottabad 22060, Pakistan

[3] Alexandru Ioan Cuza Univ, Interdisciplinary Res Dept, 54 Lascar Catargi Str, Iasi 700107, Romania

[4] Univ Laval, Fac Med, Dept Microbiol & Infectiol & Immunol, Quebec City, PQ G1V 0A6, Canada

[5] Univ Laval, CHU Quebec, Ctr Rech, Quebec City, PQ G1V 4G2, Canada

[6] Inst Chem, Lab Bioinorgan Chem & Nanocomposites, 3 Acad Str, Kishinev 2028, Moldova

[7] US DOE, Ames, IA 50011 USA

[8] Crit Mat Inst, Ames, IA 50011 USA

来源：

CHEMMEDCHEM | 2018年 / 13卷 / 21期

关键词：

antioxidants; cancer; ectonucleotidase; ionic liquids; organic salts; ANTICANCER; CELLS; INACTIVATION; DERIVATIVES; MECHANISM; AMMONIUM; CATALASE; DESIGN; ACID;

D O I：

10.1002/cmdc.201800520

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Cytotoxicity against cancer and normal cells, inhibition of ectonucleotidase, and redox properties of a new group of imidazole-based organic salts and ionic liquids were studied. The tetrachloroferrate salt of a 1-methylimidazole derivative of salicylic aldehyde had most prominent inhibitory activity against ectonucleotidase as well as a higher cytotoxicity against HeLa cells and lower cytotoxicity against BHK-21 cells than the reference compound carboplatin. The studied compounds exhibited a moderate level of antioxidant activity with better results for the salicylic aldehyde derivatives than for spiropyrans. Moreover, these compounds did not generate singlet oxygen.

引用

页码：2297 / 2304

页数：8

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