Essential Role of Nonessential Amino Acid Glutamine in Atherosclerotic Cardiovascular Disease

被引：29
|
作者：
Chen, Jinna [1 ]
Zhang, Shulei [1 ]
Wu, Jiaxiong [1 ]
Wu, Shiyuan [2 ]
Xu, Gaosheng [2 ]
Wei, Dangheng [1 ]
机构：
[1] Univ South China, Hunan Int Sci & Technol Cooperat Base Arterioscle, Prov Innovat Training Base Med Postgrad,Inst Card, Key Lab Arteriosclerol Hunan Prov,Hengyang Med Co, Hengyang, Hunan, Peoples R China
[2] YueYang Maternal Child Med Hlth Hosp Hunan, Prov Innovat Training Base Med Postgrad, Yueyang, Hunan, Peoples R China
来源：
DNA AND CELL BIOLOGY | 2020年 / 39卷 / 01期
基金：
中国国家自然科学基金;
关键词：
glutamine; atherosclerosis; macrophages polarization; ischemia-reperfusion; angiogenesis; INTESTINAL ISCHEMIA-REPERFUSION; CORONARY-ARTERY-DISEASE; NITRIC-OXIDE; OXIDATIVE STRESS; MACROPHAGE POLARIZATION; CARDIAC-FUNCTION; LUNG INJURY; IN-VITRO; CANCER; INFLAMMATION;
D O I：
10.1089/dna.2019.5034
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Atherosclerosis is a major disease that seriously harms human health and is known as the "number one killer" in developed countries and the leading cause of death worldwide. Glutamine is the most abundant nonessential amino acid in the human blood that has multifaceted effects on the body. Recent studies showed that glutamine is negatively corrected with the progression of atherosclerotic lesions. In this review, we focused on the relationship of glutamine with macrophage polarization, nitrification stress, oxidative stress injury, myocardial ischemia-reperfusion injury, and therapeutic angiogenesis to review its roles in atherosclerotic cardiovascular disease.
引用
收藏
页码：8 / 15
页数：8
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