Diagnosis and Treatment of Kaposi Sarcoma

被引：79
|
作者：
Schneider, Johann W. [1 ]
Dittmer, Dirk P. [2 ]
机构：
[1] Stellenbosch Univ, Tygerberg Hosp, Fac Med & Hlth Sci, Div Anat Pathol,Natl Hlth Lab Serv, POB 241, ZA-8000 Cape Town, South Africa
[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Dept Microbiol & Immunol, CB 7295,450 West Dr, Chapel Hill, NC 27517 USA
来源：
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY | 2017年 / 18卷 / 04期
关键词：
RECONSTITUTION INFLAMMATORY SYNDROME; AIDS MALIGNANCY CONSORTIUM; LATENT NUCLEAR ANTIGEN-1; SUB-SAHARAN AFRICA; COMBINATION ANTIRETROVIRAL THERAPY; LIPOSOMAL DAUNORUBICIN DAUNOXOME; RENAL-TRANSPLANT RECIPIENTS; RESOURCE-LIMITED SETTINGS; PRIMARY EFFUSION LYMPHOMA; MERKEL-CELL-CARCINOMA;
D O I：
10.1007/s40257-017-0270-4
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
Kaposi sarcoma (KS) is the most common neoplasm of people living with HIV today. In Sub-Saharan Africa, KS is among the most common cancers in men, overall. Not only HIV-positive individuals present with KS; any immune compromised person infected with KS-associated herpesvirus (KSHV) or human herpesvirus 8 is at risk: the elderly, children in KSHV-endemic areas, and transplant recipients. KS diagnosis is based on detection of the viral protein latency-associated nuclear antigen (LANA) in the biopsy, but not all cases of KS are the same or will respond to the same therapy. Standard KS therapy has not changed in 20 years, but newer modalities are on the horizon and will be discussed.
引用
收藏
页码：529 / 539
页数：11
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