What can biofabrication do for space and what can space do for biofabrication?

被引：22

作者：

Moroni, Lorenzo ^{[1
]}

Tabury, Kevin ^{[2
,3
]}

Stenuit, Hilde ^{[4
]}

Grimm, Daniela ^{[5
,6
]}

Baatout, Sarah ^{[2
,7
]}

Mironov, Vladimir ^{[8
]}

机构：

[1] Maastricht Univ, MERLN Inst Technol Inspired Regenerat Med, Dept Complex Tissue Regenerat, Maastricht, Netherlands

[2] Radiobiol Unit, Belgian Nucl Res Ctr, Boeretang 200, B-2400 Mol, Belgium

[3] Univ South Carolina, Dept Biomed Engn, Columbia, SC 29208 USA

[4] Space Applicat Serv, Huygensstr 34,Space Business Pk, NL-2201 DK Noordwijk, Netherlands

[5] Otto von Guericke Univ, Dept Micrograv & Translat Regenerat Med, Clin Plast Aesthet & Hand Surg, Pfalzer Pl 2, D-39106 Magdeburg, Germany

[6] Aarhus Univ, Dept Biomed, Ole Worms Alle 4, DK-8000 Aarhus C, Denmark

[7] Univ Ghent, Mol Biotechnol Lab, B-9000 Ghent, Belgium

[8] 3D Bioprinting Solut, Moscow, Russia

来源：

TRENDS IN BIOTECHNOLOGY | 2022年 / 40卷 / 04期

关键词：

MICROGRAVITY; ORGANOIDS; RADIATION; SKILLS; CHALLENGES; TISSUES;

D O I：

10.1016/j.tibtech.2021.08.008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Biofabrication in space is one of the novel promising and prospective research directions in the rapidly emerging field of space STEM. There are several advantages of biofabrication in space. Under microgravity, it is possible to engineer constructs using more fluidic channels and thus more biocompatible bioinks. Microgravity enables biofabrication of tissue and organ constructs of more complex geometries, thus facilitating novel scaffold-, label-, and nozzle-free technologies based on multi-levitation principles. However, when exposed to microgravity and cosmic radiation, biofabricated tissues could be used to study pathophysiological phenomena that will be useful on Earth and for deep space manned missions. Here, we provide leading concepts about the potential mutual benefits of the application of biofabrication technologies in space.

引用

页码：398 / 411

页数：14

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