Calcium Dependent Protein Kinases (CDPKs): Key to Malaria Eradication

被引：12
|
作者：
Kadian, Kavita [2 ]
Gupta, Yash [2 ]
Kempaiah, Prakasha [3 ]
Gupta, Nikesh [4 ]
Sharma, Arun [2 ]
Rawat, Manmeet [1 ]
机构：
[1] Univ New Mexico, Sch Med, Dept Internal Med, Albuquerque, NM 87131 USA
[2] Natl Inst Malaria Res ICMR, Prot Biochem & Struct Biol Lab, Sect 8, New Delhi, India
[3] Univ New Mexico, Hlth Sci Ctr, Dept Internal Med, Ctr Global Hlth, Albuquerque, NM 87131 USA
[4] Jawaharlal Nehru Univ, Special Ctr Nanosci, New Delhi, India
来源：
CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2017年 / 17卷 / 19期
关键词：
CDPK; Calcium signalling; Plasmodium parasites; drug target; Malaria; PARASITE PLASMODIUM-FALCIPARUM; LIFE-CYCLE; MOSQUITO TRANSMISSION; SELECTIVE INHIBITORS; PROTEOMIC ANALYSES; MOLECULAR-CLONING; PFCDPK1; EXPRESSION; GENE; MEMBRANE;
D O I：
10.2174/1568026617666170130112714
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Introduction: The family of calcium-dependent protein kinases (CDPKs) carries a kinase domain fused to a calmodulin-like domain. The presence of protein kinases devoid of clear mammalian eukaryotic protein kinase orthologues makes them potential targets for therapeutic development. Recent studies on CDPKs have inspired an important primary regulator of calcium (intracellular Ca2+ signaling), which is extensively reported to play a critical role in various stages of the apicomplexan life cycle such as microneme secretion of adhesions, cell invasion, gamete maturation, gliding motility and egress of Plasmodium Spp. Conclusion: Understanding and identifying these essential cytoregulatory components of the parasite is important for drug targets development and therapeutic intervention.
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页码：2215 / 2220
页数：6
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