Total synthesis of structurally unique γ-lactam natural products

被引：12

作者：

Takao, Ken-ichi ^{[1
]}

Aoki, Shin-ya ^{[1
]}

Tadano, Kin-ichi ^{[1
]}

机构：

[1] Keio Univ, Dept Appl Chem, Kohoku Ku, Yokohama, Kanagawa 2238522, Japan

来源：

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 2007年 / 65卷 / 05期

关键词：

natural product synthesis; total synthesis; bioactivities; gamma-lactam; spiro-heterocycles; asymmetric synthesis; stereoselective synthesis;

D O I：

10.5059/yukigoseikyokaishi.65.460

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Over the past three decades, a variety of highly functionalized gamma-lactam or spiro-heterocyclic gamma-lactam natural products have been isolated. These compounds have attracted considerable attention due to their structural uniqueness as well as interesting biological activities. Thus, numerous synthetic organic chemists have established new methodologies for access to the gamma-lactam-type compounds. In this review, we summarize completed total syntheses of natural products containing a gamma-lactam structure, such as (-)-PI-091, (+)-epolactaene, lucilactaene, (-)-pramanicin, (-)-pseurotin A, (-)-pseurotin F-2, (+)-synerazol, and (-)-azaspirene.

引用

页码：460 / 469

页数：10

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