Repressive BMP2 gene regulatory elements near the BMP2 promoter

被引：8

作者：

Jiang, Shan

Chandler, Ronald L. ^{[2
]}

Fritz, David T.

Mortlock, Douglas P. ^{[2
]}

Rogers, Melissa B. ^{[1
]}

机构：

[1] Univ Med & Dent New Jersey, Dept Biochem & Mol Biol, MSB E627, NJMS, Newark, NJ 07101 USA

[2] Vanderbilt Univ, Dept Mol Physiol & Biophys, Ctr Human Genet Res, Sch Med, Nashville, TN 37232 USA

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2010年 / 392卷 / 02期

关键词：

Bone morphogenetic protein 2 (BMP2); Gene regulation; Transgenic mice; Fibroblast growth factor (FGF2); Osteoblast; Enhancer; BONE MORPHOGENETIC PROTEIN-2; EXPRESSION; TRANSCRIPTION; MOUSE; DIFFERENTIATION; IDENTIFICATION; ALPHA; CHONDROCYTES; STIMULATION; ANTAGONISTS;

D O I：

10.1016/j.bbrc.2009.12.157

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The level of bone morphogenetic protein 2 (BMP2) profoundly influences essential cell behaviors such as proliferation, differentiation, apoptosis, and migration. The spatial and temporal pattern of BMP2 synthesis, particular in diverse embryonic cells, is highly varied and dynamic. We have identified GC-rich sequences within the BMP2 promoter region that strongly repress gene expression. These elements block the activity of a highly conserved, osteoblast enhancer in response to FGF2 treatment. Both positive and negative gene regulatory elements control BMP2 synthesis. Detecting and mapping the repressive motifs is essential because they impede the identification of developmentally regulated enhancers necessary for normal BMP2 Patterns and concentration. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：124 / 128

页数：5

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