Complete genomic sequence and an infectious BAC clone of feline herpesvirus-1 (FHV-1)

被引：33
|
作者：
Tai, S. H. Sheldon [2 ]
Niikura, Masahiro [3 ,4 ]
Cheng, Hans H. [2 ,4 ]
Kruger, John M. [2 ,5 ]
Wise, Annabel G. [1 ,2 ]
Maes, Roger K. [1 ,2 ,3 ]
机构：
[1] Michigan State Univ, Coll Vet Med, Diagnost Ctr Populat & Anim Hlth, Lansing, MI 48910 USA
[2] Michigan State Univ, Coll Vet Med, Grad Program Comparat Med & Integrat Biol, E Lansing, MI 48824 USA
[3] Michigan State Univ, Coll Vet Med, Dept Microbiol & Mol Genet, E Lansing, MI 48824 USA
[4] ARS, USDA, Avian Dis & Oncol Lab, E Lansing, MI 48823 USA
[5] Michigan State Univ, Coll Vet Med, Dept Small Anim Clin Sci, E Lansing, MI 48824 USA
来源：
VIROLOGY | 2010年 / 401卷 / 02期
关键词：
Feline herpesvirus; FHV-1; Genomic sequence; Infectious BAC clone; BACTERIAL ARTIFICIAL CHROMOSOME; COMPLETE DNA-SEQUENCE; HUMAN CYTOMEGALOVIRUS; ESCHERICHIA-COLI; TRANSPOSON MUTAGENESIS; VIRAL RHINOTRACHEITIS; PSEUDORABIES VIRUS; GLYCOPROTEINS GI; IN-VITRO; CONSTRUCTION;
D O I：
10.1016/j.virol.2010.02.021
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Infection with feline herpesvirus-1 (FHV-1) is a major cause of upper respiratory and ocular diseases in Felidae. We report the first complete genomic sequence of FHV-1, as well as the construction and characterization of a bacterial artificial chromosome (BAC) clone of FHV-1, which contains the entire FHV-1 genome and has the BAC vector inserted at the left end of U-L. Complete genomic sequences were derived from both the FHV-1 BAC clone and purified virion DNA. The FHV-1 genome is 135,797 bp in size with an overall G + C content of 45%. A total of 78 open reading frames were predicted, encoding 74 distinct proteins. The gene arrangement is collinear with that of most sequenced varicelloviruses. The virus regenerated from the BAC was very similar to the parental C-27 strain in vitro in terms of plaque morphology and growth characteristics and highly virulent in cats in a preliminary in vivo study. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：215 / 227
页数：13
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