Clostridium innocuum infection in hospitalised patients with inflammatory bowel disease

被引:9
|
作者
Le, Puo-Hsien [1 ,2 ,3 ]
Chiu, Cheng-Tang [1 ,2 ]
Yeh, Pai-Jui [4 ]
Pan, Yu-Bin [5 ]
Chiu, Cheng-Hsun [6 ,7 ]
机构
[1] Chang Gung Mem Hosp, Dept Gastroenterol & Hepatol, Linkou Branch, Taoyuan, Taiwan
[2] Taiwan Assoc Study Small Intestinal Dis, Taoyuan, Taiwan
[3] Chang Gung Mem Hosp, Liver Res Ctr, Linkou Branch, Taoyuan, Taiwan
[4] Chang Gung Mem Hosp, Dept Pediat, Div Pediat Gastroenterol, Linkou Branch, Taoyuan, Taiwan
[5] Chang Gung Mem Hosp, Clin Trial Ctr, Linkou Branch, Biostat Sect, Taoyuan, Taiwan
[6] Chang Gung Mem Hosp, Dept Pediat, Div Pediat Infect Dis, Linkou Branch, 5 Fu Hsin St, Taoyuan 333, Taiwan
[7] Chang Gung Mem Hosp, Mol Infect Dis Res Ctr, Linkou Branch, Taoyuan, Taiwan
关键词
Clostridium innocuum; Inflammatory bowel disease; Crohn's disease; Ulcerative colitis; Vancomycin resistance; DIFFICILE; CARRIAGE; DIARRHEA;
D O I
10.1016/j.jinf.2021.12.031
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Background: Clostridium innocuum (CI) infection can lead to creeping fat in Crohn's disease and is associated with intestinal strictures. At present, no clinical study ever has evaluated the role of CI infection in inflammatory bowel disease (IBD). Materials and methods: In this retrospective cohort study, we enrolled hospitalized IBD patients with culture results for both CI and Clostridioides difficile (CD) in a medical center between October 2019 and April 2021. They were divided into the CI (CI+/CD-), control (CI-/CD-), coinfection (CI+ /CD+), and CD (CI-/ CD+) groups. We analyzed the risk factors, clinical presentations, and outcomes by comparing the CI and control groups. Results: We enrolled a total of 90 patients, including 22, 39, 13, and 16 patients in the CI, control, co-infection, and CD groups. The incidence rates of CI (CI+) and CD (CD+) were 39% (35/90) and 32% (29/90), respectively. We analyzed the differences between CI and control groups. We identified the use of steroid (77.3% vs. 46.2%, P = 0.018) and 5-aminosalicylic acid (90.9% vs. 64.1%, P = 0.022) as risk factors of CI infection. Clinical analysis showed that more patients in CI group presented with bloody stool (77.3% vs. 51.3%, P = 0.046). Although CI group had significantly lower overall occurrence of intraabdominal abscess (0% vs. 17.9%, P = 0.042), it showed a lower clinical remission rate (50% vs. 87.5%, P = 0.044) and higher Mayo score at the end of follow-up (10 points vs. 3 points, P = 0.008) in ulcerative colitis. Conclusions: CI infection may lead to a poorer clinical remission in ulcerative colitis. We should take it into consideration in IBD patents with active inflamamtion or refractory diarrhea with or without CD infection. Precise identification of CI is imperative to guide approproate antimicrobial therapy because of its intrinsic vancomycin resistance nature. (C) 2021 Published by Elsevier Ltd on behalf of The British Infection Association.
引用
收藏
页码:337 / 342
页数:6
相关论文
共 50 条
  • [1] Clostridium innocuum Infection in Inpatients with Inflammatory Bowel Disease
    Le, P. H.
    Chiu, C. H.
    Chiu, C. T.
    [J]. JOURNAL OF CROHNS & COLITIS, 2022, 16 : I243 - I243
  • [2] Prevalence of Clostridium difficile infection among hospitalised inflammatory bowel disease patients in Greece
    Viazis, N.
    Pontas, C.
    Belesiotou, E.
    Karmiris, K.
    Dimas, I.
    Fragaki, M.
    Paspatis, G.
    Banasa, M.
    Drygiannakis, I.
    Koutroubakis, I.
    Maraki, S.
    Moschovis, D.
    Tzouvala, M.
    Kouskoumpekou, F.
    Theocharis, G.
    Tsolias, C.
    Thomopoulos, K.
    Apostolopoulos, G.
    Stamouli, V.
    Zampeli, E.
    Axiaris, G.
    Michopoulos, S.
    Prifti, H.
    Mantzaris, G. J.
    [J]. JOURNAL OF CROHNS & COLITIS, 2018, 12 : S561 - S561
  • [3] Opportunistic Infection in Hospitalised Patients with Inflammatory Bowel Disease
    Zhou, Jin-Qiu
    Meng, Zhang-Min
    Zhang, Tao
    Jing, Xing-Tao
    Gan, Hua-Tian
    [J]. JCPSP-JOURNAL OF THE COLLEGE OF PHYSICIANS AND SURGEONS PAKISTAN, 2020, 30 (10): : 1015 - 1020
  • [4] Does corticosteroid therapy affect prognosis in inflammatory bowel disease patients hospitalised with Clostridium difficile infection?
    Bar Yoseph, H.
    Daoud, H.
    Ben Hur, D.
    Chowers, Y.
    Waterman, M.
    [J]. JOURNAL OF CROHNS & COLITIS, 2019, 13 : S367 - S367
  • [5] Clostridium difficile infection in patients with inflammatory bowel disease
    Czepiel, Jacek
    Biesiada, Grazyna
    Perucki, William
    Mach, Tomasz
    [J]. PRZEGLAD GASTROENTEROLOGICZNY, 2014, 9 (03): : 125 - 129
  • [6] Clostridium Difficile Infection in Patients with Inflammatory Bowel Disease
    Joshi, N. M.
    Rampton, D. S.
    [J]. PRACTICAL GASTROENTEROLOGY, 2012, 36 (11) : 16 - +
  • [7] Clostridium difficile Infection in Patients with Inflammatory Bowel Disease
    Fu, Nancy
    Wong, Titus
    [J]. CURRENT INFECTIOUS DISEASE REPORTS, 2016, 18 (06)
  • [8] Clostridium difficile infection in patients with inflammatory bowel disease
    Saidel-Odes, Lisa
    Borer, Abraham
    Odes, Selwyn
    [J]. ANNALS OF GASTROENTEROLOGY, 2011, 24 (04): : 263 - 270
  • [9] Clostridium Difficile Infection in Inflammatory Bowel Disease Patients
    Albarrak, Abdulmajeed A.
    Romana, Bhupinder S.
    Uraz, Suleyman
    Yousef, Mohamad H.
    Juboori, Alhareth A.
    Tahan, Veysel
    [J]. ENDOCRINE METABOLIC & IMMUNE DISORDERS-DRUG TARGETS, 2019, 19 (07) : 929 - 935
  • [10] Clostridium difficile Infection in Patients with Inflammatory Bowel Disease
    Nancy Fu
    Titus Wong
    [J]. Current Infectious Disease Reports, 2016, 18