Investigating the potential protective effects of natural product quercetin against imidacloprid-induced biochemical toxicity and DNA damage in adults rats

Quercetin (QT) is a natural antioxidant materials that's possesses different type of pharmacological activities. In the current study, the protective effect QT against imidacloprid (IMD)-induced toxicity in rats was studied. The experiment included thirty-six adult male rats groups treated with QT, IMD (two different doses), their combinations and control non-treated group for 21 consecutive days. Different biochemical analysis (serum liver and kidney enzymes level, cholesterol and Glucose levels) were evaluated. DNA damage using comet assay and histopathological examination of different body organs were also screened. Treatment with IMD increased ALT, AST, serum urea, creatinine, cholesterol and Glucose levels but decreased the levels of serum total protein, albumin and body weight with induction in triacylglycerol and cholesterol levels. Animals treated with QT prior to IMD administration showed normal enzymatic levels which indicating a protective effect of QT. In addition, QT protected the different body organs from the histological changes and DNA damages induced by IMD toxicity. The present results showed the protective effect of QT as a natural material against the IMD induced toxicity at different doses.