Recent developments and future directions in computational genomics
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Tsoka, S
[1
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Ouzounis, CA
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EMBL, European Bioinformat Inst, Computat Gen Grp, Res Programme,Cambridge Outstn, Cambridge CB10 1SD, EnglandEMBL, European Bioinformat Inst, Computat Gen Grp, Res Programme,Cambridge Outstn, Cambridge CB10 1SD, England
Ouzounis, CA
[1
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[1] EMBL, European Bioinformat Inst, Computat Gen Grp, Res Programme,Cambridge Outstn, Cambridge CB10 1SD, England
Computational genomics is a subfield of computational biology that deals with the analysis of entire genome sequences. Transcending the boundaries of classical sequence analysis, computational genomics exploits the inherent properties of entire genomes by modelling them as systems. We review recent developments in the field, discuss in some detail a number of novel approaches that take into account the genomic context and argue that progress will be made by novel knowledge representation and simulation technologies. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
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Royal Hallamshire Hosp, Acad Dept Gastroenterol, Sheffield, S Yorkshire, EnglandRoyal Hallamshire Hosp, Acad Dept Gastroenterol, Sheffield, S Yorkshire, England
Chetcuti Zammit, Stefania
Sidhu, Reena
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Royal Hallamshire Hosp, Acad Dept Gastroenterol, Sheffield, S Yorkshire, EnglandRoyal Hallamshire Hosp, Acad Dept Gastroenterol, Sheffield, S Yorkshire, England