Reinforcing and discriminative-stimulus effects of two pyrrolidine-containing synthetic cathinone derivatives in rats

被引：9
|
作者：
Xu, Peng [1 ]
Lai, Miaojun [2 ]
Fu, Dan [2 ]
Liu, Huifen [2 ]
Wang, Youmei [1 ]
Shen, Haowei [3 ]
Zhou, Wenhua [2 ]
机构：
[1] Minist Publ Secur, Drug Intelligence & Forens Ctr, Key Lab Drug Monitoring & Control, Beijing 100093, Peoples R China
[2] Ningbo Univ, Ningbo Kangning Hosp, Sch Med, Zhejiang Prov Key Lab Addict, Ningbo 315201, Zhejiang, Peoples R China
[3] Ningbo Univ, Fac Physiol & Pharmacol, Sch Med, Ningbo 315211, Zhejiang, Peoples R China
来源：
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR | 2021年 / 203卷
基金：
中国国家自然科学基金;
关键词：
Reinforcement; Abuse liability; New psychoactive substance; Methamphetamine; Cathinone; SALT CONSTITUENT 3,4-METHYLENEDIOXYPYROVALERONE; CENTRAL-NERVOUS-SYSTEM; BATH SALTS; HEROIN-SEEKING; ALPHA-PYRROLIDINOPENTIOPHENONE; LOCOMOTOR-ACTIVITY; DOPAMINE; POTENCY; MDPV; PVP;
D O I：
10.1016/j.pbb.2021.173128
中图分类号：
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号：
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要：
The molecular and behavioral aspects of alpha-pyrrolidinopentiophenone (alpha-PVP) have been characterized; however, how the structural modification of alpha-PVP affects its abuse potential is still unknown. In this study, we investigated the abuse potential of two pyrrolidinylated second-generation cathinones:4-chloro-alpha-pyrrolidinopentiophenone (4cl-alpha-PVP) and 4-chloro-alpha-pyrrolidinopropiophenone (4cl-alpha-PPP). Male Sprague-Dawley rats were trained to self-administer methamphetamine (METH, 0.05 mg.kg(-1).infusion(-1)), alpha-PVP (0.05 mg.kg(-1).infusion(-1)), 4cl-alpha-PVP (0.05 mg.kg(-1).infusion(-1)), and 4cl-alpha-PPP (0.5 mg.kg(-1).infusion(-1)) under a fixed ratio (FR)(-1) reinforcement schedule for-10 sessions. The discriminative-stimulus effect of METH (0.8 mg/kg) from saline was tested under an FR10 schedule of food delivery. alpha-PVP, 4cl-alpha-PVP and 4cl-alpha-PPP produced reinforcement behaviors and presented an inverted U-shaped dose effect. The reinforcing potency was displayed with a rank order of alpha-PVP (0.029 mg.kg(-1).infusion(-1)) > METH (0.040 mg.kg(-1).infusion(-1)) > 4cl-alpha-PVP (0.094 mg.kg(-1).infusion(-1)) > 4cl-alpha-PPP (0.51 mg.kg(-1).infusion(-1)). All three drugs were fully substituted for the discriminative-stimulus effects of METH in rats. The substitution potency for discriminative-stimulus effects of alpha-PVP (ED50 = 0.4 mg/kg) was approximately equal to that of METH (ED50 = 0.3 mg/kg), while the discriminative potency of 4cl-alpha-PVP (ED50 =-1.0 mg/kg) and 4cl-alpha-PPP (ED50 = 5 mg/kg) was approximately 3 and-16-fold less than that of METH. The rank order of potency was alpha-PVP approximate to METH > 4cl-alpha-PVP > 4cl-alpha-PPP. The present data demonstrated that 4cl-alpha-PVP and 4cl-alpha-PPP produced reinforcing effects and fully and dose-dependently substituted for the subjective effects of METH, suggesting that both 4cl-alpha-PVP and 4cl-alpha-PPP have abuse potential that may be similar to METH.
引用
收藏
页数：6
相关论文
共 50 条
  • [1] Reinforcing Effects and Discriminative Stimulus Effects of Three Pyrrolidine-Containing Synthetic Cathinones Derivatives in Rats
    LAI Miao-jun
    FU Dan
    XU Wen-jin
    LIU Hui-fen
    XU Peng
    ZHOU Wen-hua
    [J]. 神经药理学报, 2019, 9 (04) : 23 - 23
  • [2] Comparative Behavioral Pharmacology of Three Pyrrolidine-Containing Synthetic Cathinone Derivatives
    Gatch, Michael B.
    Dolan, Sean B.
    Forster, Michael J.
    [J]. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2015, 354 (02): : 103 - 110
  • [3] The psychomotor, reinforcing, and discriminative stimulus effects of synthetic cathinone mexedrone in male mice and rats
    Jeon, Kyung Oh
    Kim, Oc-Hee
    Seo, Su Yeon
    Yun, Jaesuk
    Jang, Choon-Gon
    Lim, Ri-Na
    Kim, Tae Wan
    Yang, Chae Ha
    Yoon, Seong Shoon
    Jang, Eun Young
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2024, 969
  • [4] Mephedrone: a Synthetic Cathinone with Marked Serotonergic Discriminative Stimulus Effects in Rats
    Erwin, Laura Lynn
    Jursic, Bronco
    Winsauer, Peter
    [J]. FASEB JOURNAL, 2017, 31
  • [5] Reinforcing and discriminative-stimulus effects of ephedrine isomers in rhesus monkeys
    Anderson, KG
    Winger, G
    Woods, J
    Woolverton, WL
    [J]. DRUG AND ALCOHOL DEPENDENCE, 2001, 65 (01) : 45 - 53
  • [6] Discriminative-Stimulus Effects of Synthetic Cathinones in Squirrel Monkeys
    Wakeford, Alison G. P.
    Sherwood, Alexander M.
    Prisinzano, Thomas E.
    Bergman, Jack
    Kohut, Stephen J.
    Paronis, Carol A.
    [J]. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2021, 24 (08): : 656 - 665
  • [7] Dopaminergic involvement in the discriminative-stimulus effects of methamphetamine in rats
    P. Munzar
    S. R. Goldberg
    [J]. Psychopharmacology, 2000, 148 : 209 - 216
  • [8] Caffeine potentiates the discriminative-stimulus effects of nicotine in rats
    Gasior, M
    Jaszyna, M
    Munzar, P
    Witkin, JM
    Goldberg, SR
    [J]. PSYCHOPHARMACOLOGY, 2002, 162 (04) : 385 - 395
  • [9] Adenosinergic modulation of the discriminative-stimulus effects of methamphetamine in rats
    Patrik Munzar
    Zuzana Justinova
    Scott W. Kutkat
    Sergi Ferré
    Steven R. Goldberg
    [J]. Psychopharmacology, 2002, 161 : 348 - 355
  • [10] Adenosinergic modulation of the discriminative-stimulus effects of methamphetamine in rats
    Munzar, P
    Justinova, Z
    Kutkat, SW
    Ferré, S
    Goldberg, SR
    [J]. PSYCHOPHARMACOLOGY, 2002, 161 (04) : 348 - 355
12345