Obesity-induced Hypertension: Role of Sympathetic Nervous System, Leptin, and Melanocortins

被引：373

作者：

Hall, John E. ^{[1
]}

da Silva, Alexandre A. ^{[1
]}

do Carmo, Jussara M. ^{[1
]}

Dubinion, John ^{[1
]}

Hamza, Shereen ^{[1
]}

Munusamy, Shankar ^{[1
]}

Smith, Grant ^{[1
]}

Stec, David E. ^{[1
]}

机构：

[1] Univ Mississippi, Med Ctr, Dept Physiol & Biophys, Jackson, MS 39216 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 2010年 / 285卷 / 23期

基金：

美国国家卫生研究院;

关键词：

BLOOD-PRESSURE; ARTERIAL-PRESSURE; MICE; ACTIVATION; EPIDEMICS; WEIGHT; KIDNEY;

D O I：

10.1074/jbc.R110.113175

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Excess weight gain contributes to increased blood pressure in most patients with essential hypertension. Although the mechanisms of obesity hypertension are not fully understood, increased renal sodium reabsorption and impaired pressure natriuresis play key roles. Several mechanisms contribute to altered kidney function and hypertension in obesity, including activation of the sympathetic nervous system, which appears to be mediated in part by increased levels of the adipocyte-derived hormone leptin, stimulation of pro-opiomelanocortin neurons, and subsequent activation of central nervous system melanocortin 4 receptors.

引用

页码：17271 / 17276

页数：6

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