Nitric oxide affects LTP in area CA1 and CA3 of hippocampus in low-level lead-exposed rat

被引：29
|
作者：
Xu, YZ [1 ]
Ruan, DY [1 ]
Wu, Y [1 ]
Jiang, YB [1 ]
Chen, SY [1 ]
Chen, JT [1 ]
Shi, P [1 ]
机构：
[1] Univ Sci & Technol China, Dept Biol, Hefei 230027, Anhui, Peoples R China
来源：
NEUROTOXICOLOGY AND TERATOLOGY | 1998年 / 20卷 / 01期
基金：
中国国家自然科学基金;
关键词：
lead; nitric oxide; LTP; hippocampal slice;
D O I：
10.1016/S0892-0362(97)00072-X
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neonatal Wistar rats were exposed to lead from parturition to weaning via the milk of dams drinking 0.2% lead acetate solution. The alterations in EPSPs in areas CA1 and CA3 of hippocampal slices of 60-day-old adult rats following developmental lead exposure were studied. The results demonstrate that lead exposure in neonatal rats causes a decrease in LTP in area CA1 and an increase in LTP in area CA3. The effects of exposure to NO-generating compound sodium nitroprusside (SNP) on LTP in areas CA1 and CA3 of control and lead-exposed rats were also tested. The data demonstrate that NO causes an increase in LTP in area CA1 and no different alterations in area CA3 of lead-exposed rats. The results also demonstrate that NO may be a messenger molecule in areas CA1 and CA3. It suggests that lead might selectively interfere with specific neurochemical pathways in the hippocampus. (C) 1998 Elsevier Science Inc.
引用
收藏
页码：69 / 73
页数：5
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