Everything you need to know about distal renal tubular acidosis in autoimmune disease

被引：42
|
作者：
Both, Tim [1 ]
Zietse, Robert [2 ]
Hoorn, Ewout J. [2 ]
van Hagen, P. Martin [1 ]
Dalm, Virgil A. S. H. [1 ]
van Laar, Jan A. M. [1 ]
van Daele, Paul L. A. [1 ]
机构：
[1] Erasmus MC, Dept Internal Med, Div Clin Immunol, NL-3000 CA Rotterdam, Netherlands
[2] Erasmus MC, Dept Internal Med, Div Nephrol & T ransplantat, NL-3000 CA Rotterdam, Netherlands
来源：
RHEUMATOLOGY INTERNATIONAL | 2014年 / 34卷 / 08期
关键词：
Autoimmunity; Renal physiology; Acid-base balance; THICK ASCENDING LIMB; BONE-MINERAL DENSITY; METABOLIC-ACIDOSIS; AMMONIUM TRANSPORT; SJOGRENS-SYNDROME; KIDNEY; H+; RAT; NA+; MECHANISMS;
D O I：
10.1007/s00296-014-2993-3
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Renal acid-base homeostasis is a complex process, effectuated by bicarbonate reabsorption and acid secretion. Impairment of urinary acidification is called renal tubular acidosis (RTA). Distal renal tubular acidosis (dRTA) is the most common form of the RTA syndromes. Multiple pathophysiologic mechanisms, each associated with various etiologies, can lead to dRTA. The most important consequence of dRTA is (recurrent) nephrolithiasis. The diagnosis is based on a urinary acidification test. Potassium citrate is the treatment of choice.
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页码：1037 / 1045
页数：9
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