Tandem duplication in ermC translational attenuator of the macrolide-lincosamide-streptogramin B resistance plasmid pSES6 from Staphylococcus equorum

被引：23
|
作者：
Lodder, G [1 ]
Schwarz, S [1 ]
Gregory, P [1 ]
Dyke, K [1 ]
机构：
[1] UNIV OXFORD,DEPT BIOCHEM,MICROBIOL UNIT,OXFORD OX1 3QU,ENGLAND
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1996年 / 40卷 / 01期
关键词：
D O I：
10.1128/AAC.40.1.215
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A tandem duplication of 23 bp in the ermC gene translational attenuator of plasmid pSES6 from Staphylococcus equorum which mediated constitutive resistance to macrolide-lincosamide-streptogramin B antibiotics was identified. This duplication included the ribosome binding site for the ermC gene as well as the first 5 bp of the ermC coding sequence. It was postulated that this sequence duplication affects the possible RNA conformations so that the,ribosome binding site for ErmC synthesis is readily accessible to the ribosomes and thus constitutive expression of the ermC gene occurs.
引用
收藏
页码：215 / 217
页数：3
相关论文
共 43 条
  • [1] Macrolide-Lincosamide-Streptogramin B Resistance Phenotypes in Staphylococcus Aureus
    Durmaz, Suleyman
    Kiraz, Asli
    Ozer, Turkan Toka
    Percin, Duygu
    EUROPEAN JOURNAL OF GENERAL MEDICINE, 2014, 11 (04): : 217 - 220
  • [2] A STAPHYLOCOCCUS-AUREUS PLASMID THAT SPECIFIES CONSTITUTIVE MACROLIDE-LINCOSAMIDE-STREPTOGRAMIN-B RESISTANCE CONTAINS A NOVEL DELETION IN THE ERMC ATTENUATOR
    CATCHPOLE, I
    DYKE, KGH
    FEMS MICROBIOLOGY LETTERS, 1990, 69 (1-2) : 43 - 47
  • [3] Phenotypic Characterization of Macrolide-Lincosamide-Streptogramin B Resistance in Staphylococcus aureus
    Modukuru, Giridhar Kumar
    Surya, Pradeep Madala Sobhana
    Kakumanu, Vishnuvardhana Rao
    Yarava, Saritha
    JOURNAL OF PURE AND APPLIED MICROBIOLOGY, 2021, 15 (02): : 689 - 694
  • [4] Phenotypical examination of the macrolide-lincosamide-streptogramin B resistance in Staphylococcus isolates
    Ozbek, Erdal
    Temiz, Hakan
    Tekay, Fikret
    Kalayci, Raike
    Akkoc, Hasan
    AFRICAN JOURNAL OF MICROBIOLOGY RESEARCH, 2012, 6 (13): : 3292 - 3296
  • [5] Macrolide-lincosamide-streptogramin B resistance in Staphylococcus lentus results from the integration of part of a transposon into a small plasmid
    Werckenthin, C
    Schwarz, S
    Dyke, K
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1996, 40 (09) : 2224 - 2225
  • [6] New Macrolide-Lincosamide-Streptogramin B Resistance Gene erm(48) on the Novel Plasmid pJW2311 in Staphylococcus xylosus
    Wipf, Juliette R. K.
    Riley, Matthew C.
    Kania, Stephen A.
    Bemis, David A.
    Andreis, Sabrina
    Schwendener, Sybille
    Perreten, Vincent
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2017, 61 (07)
  • [7] PRJ5 - A NATURALLY-OCCURRING STAPHYLOCOCCUS-AUREUS PLASMID EXPRESSING CONSTITUTIVE MACROLIDE LINCOSAMIDE STREPTOGRAMIN-B RESISTANCE CONTAINS A TANDEM DUPLICATION IN THE LEADER REGION OF THE ERMC GENE
    OLIVEIRA, SS
    MURPHY, E
    GAMON, MR
    BASTOS, MCF
    JOURNAL OF GENERAL MICROBIOLOGY, 1993, 139 : 1461 - 1467
  • [8] Macrolide-Lincosamide-Streptogramin B (MLSB) Resistance Phenotypes in Clinical Staphylococcus Isolates and Investigation of Telithromycin Activity
    Uzun, Berrin
    Gungor, Serdar
    Pektas, Bayram
    Aksoy Gokmen, Aysegul
    Yula, Erkan
    Kocal, Funda
    Kaya, Selcuk
    MIKROBIYOLOJI BULTENI, 2014, 48 (03): : 469 - 476
  • [9] The Novel Macrolide-Lincosamide-Streptogramin B Resistance Gene erm(44) Is Associated with a Prophage in Staphylococcus xylosus
    Wipf, Juliette R. K.
    Schwendener, Sybille
    Perreten, Vincent
    ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (10) : 6133 - 6138
  • [10] Macrolide-lincosamide-streptogramin B resistance phenotypes and genotypes among Staphylococcus aureus clinical isolates in Japan
    Otsuka, T.
    Zaraket, H.
    Takano, T.
    Saito, K.
    Dohmae, S.
    Higuchi, W.
    Yamamoto, T.
    CLINICAL MICROBIOLOGY AND INFECTION, 2007, 13 (03) : 325 - 327
12345