The tumor immune microenvironment in gastroenteropancreatic neuroendocrine neoplasms

被引：29
|
作者：
Zhang, Wu-Hu [1 ,2 ,3 ,4 ]
Wang, Wen-Quan [1 ,2 ,3 ,4 ]
Gao, He-Li [1 ,2 ,3 ,4 ]
Yu, Xian-Jun [1 ,2 ,3 ,4 ]
Liu, Liang [1 ,2 ,3 ,4 ]
机构：
[1] Fudan Univ, Shanghai Canc Ctr, Dept Pancreat Surg, Shanghai, Peoples R China
[2] Fudan Univ, Shanghai Med Coll, Dept Oncol, Shanghai, Peoples R China
[3] Shanghai Pancreat Canc Inst, Shanghai, Peoples R China
[4] Fudan Univ, Pancreat Canc Inst, Shanghai, Peoples R China
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER | 2019年 / 1872卷 / 02期
基金：
美国国家科学基金会; 中国国家自然科学基金;
关键词：
Gastroenteropancreatic neuroendocrine neoplasms; Tumor immune microenvironment; Immunotherapy; Immune checkpoint inhibitors; Biomarkers; TO-LYMPHOCYTE RATIO; BREAST-CANCER; ANTITUMOR-ACTIVITY; ANGIOGENIC SWITCH; PERIPHERAL-BLOOD; PD-L1; EXPRESSION; CELL-GROWTH; MOUSE MODEL; MACROPHAGES; CD73;
D O I：
10.1016/j.bbcan.2019.188311
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a group of rare tumors that are increasing in prevalence. The complex tumor immune microenvironment (TIME) plays an important role in tumor development and the response to immunotherapy but is poorly understood. In this review, the components of the TIME are described in detail, including discussion about infiltrating immune cells, the immune checkpoint system, the cytokine and chemokine milieu, and immunomodulatory factors. Moreover, a comparison between TIMEs among different types of GEP-NENs and the interplay among the TIME, tumor cells, and the stromal microenvironment is described. Novel treatment options for GEP-NENs and potential biomarkers for the immune response are also characterized. We provide a comprehensive generalized review of the TIME that can inform GEP-NEN treatment strategies.
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收藏
页数：11
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