Synthesis and antibacterial activity of some chalcones

The chalcones derived from quinoline aldehyde were (2E)-3-(2-chlorobenzo[h]quitiolin-3-yl)-1-(4-methoxyphenyl)prop-2-en-1-one (RM-1), (2E)-3-(2-chlorobenzo[h]quinolin-3-yl)-1-(4-methylphenyl)prop-2-en-1-one (RM-2), (2E)-3-(2-chlorobenzo[h]quinolin-3-yl)-1-(4-chlorophenyl)prop-2-en-1-one (RM-3), (2E)-1-(4-bromopheny1)-3-(2chlorobenzo[h]quinolin-3-yl)prop-2-en-1-one (RM-4), (2E)-3-(2-chlorobenzo[h]quinolin-3-yl)-1-(4-nitrophenyl)prop-2-en-1-one (RM-5), (2E)-1-(4-aminophenyl)-3-(2-chlorobenzo[h]quinolin-3-yl)prop-2-en-1-one (RM-6), (2E)-3-(2chlorobenzo[h]quinolin-3-yl)-1-(3-nitrophenyl)prop-2-en-1-one (RM-7), (2E)-3-(2-chlorobenzo[h]quinolin-3-yl)-1-(2-hydroxyphenyl)prop-2-en-1-one (RM-8), (2E)-3-(2-chlorobenzo[h]quinolin-3-yl)-1-(4-hydroxyphenyl)prop-2-en-1-one (RM-9), (2E)-3-(2-chlorobenzo[h]quinolin-3-yl)-1-phenylprop-2-en-1-one (RM-10). Chalcones were evaluated for their potential as antibacterial agents against three Gram-positive bacteria Bacillus cereus, Staphylococcus aureus, Micrococcus flavus and three Gram-negative bacteria Proteus mirabilis. Escherichia coli. Klebsiella pneumoniae. The antibacterial assay was evaluated by agar disc diffusion method in DMF solvent.