Role of Benzylic Deprotonation in Nickel-Catalyzed Benzylic Dehydrogenation

被引：4

作者：

Zhang, Pengpeng ^{[1
]}

Cantrell, Rachel L. ^{[1
]}

Newhouse, Timothy R. ^{[1
]}

机构：

[1] Yale Univ, Dept Chem, 225 Prospect St, New Haven, CT 06520 USA

来源：

SYNLETT | 2021年 / 32卷 / 16期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Ni catalysis; dehydrogenation; benzylic anion; heteroarene; deuteration; ASYMMETRIC ALLYLIC ALKYLATIONS; ELECTROPHILIC AMINATION; SUBSTITUTION; NUCLEOPHILES; ARYLATION; ZINCATION; BASE;

D O I：

10.1055/s-0040-1720446

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Alkylarenes are readily functionalized via the corresponding benzylic anions. Benzylic anions have been used for a range of catalytic reactions, including Ni-catalyzed dehydrogenation. Interestingly, the employment of Zn(TMP)(2) for slow and incomplete deprotonation of the benzylic position was observed. This manuscript describes a preliminary investigation into the deprotonation of heteroarenes and its relationship to Ni-catalyzed benzylic dehydrogenation.

引用

页码：1652 / 1656

页数：5

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