Reprint of: Microglial toll-like receptors and Alzheimer's disease

被引：11

作者：

Su, Fan ^{[1
]}

Bai, Feng ^{[1
]}

Zhou, Hong ^{[1
]}

Zhang, Zhijun ^{[1
]}

机构：

[1] Southeast Univ, Sch Med, Affiliated ZhongDa Hosp, Dept Neurol, Nanjing 210009, Jiangsu, Peoples R China

来源：

BRAIN BEHAVIOR AND IMMUNITY | 2016年 / 55卷

基金：

中国国家自然科学基金; 国家教育部博士点专项基金资助;

关键词：

Alzheimer's disease; Toll-like receptors; Microglia; Neuroinflammation; AMYLOID-BETA-PEPTIDE; MILD COGNITIVE IMPAIRMENT; PRO-INFLAMMATORY CYTOKINE; MOUSE MODEL; UP-REGULATION; INTRON-II; PRECURSOR PROTEIN; TLR2; RECEPTOR; MICROSATELLITE POLYMORPHISMS; MEDIATES NEURODEGENERATION;

D O I：

10.1016/j.bbi.2016.05.016

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Microglial activation represents an important pathological hallmark of Alzheimer's disease (AD), and emerging data highlight the involvement of microglial toll-like receptors (TLRs) in the course of AD. TLRs have been observed to exert both beneficial and detrimental effects on AD-related pathologies, and transgenic animal models have provided direct and credible evidence for an association between TLRs and AD. Moreover, analyses of genetic polymorphisms have suggested interactions between genetic polymorphisms in TLRs and AD risk, further supporting the hypothesis that TLRs are involved in AD. In this review, we summarize the key evidence in this field. Future studies should focus on exploring the mechanisms underlying the potential roles of TLRs in AD. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：166 / 178

页数：13

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