Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data

被引：23
|
作者：
Kos, Veronica N. [1 ]
McLaughlin, Robert E. [1 ]
Gardner, Humphrey A. [2 ]
机构：
[1] AstraZeneca R&D Boston, Infect Innovat Medicines Unit, Waltham, MA USA
[2] AstraZeneca R&D Boston, Early Clin Dev Innovat Med Unit, Waltham, MA USA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2016年 / 60卷 / 06期
关键词：
BETA-LACTAM RESISTANCE; PENICILLIN-BINDING PROTEINS; CYSTIC-FIBROSIS PATIENTS; CITROBACTER-FREUNDII; GENE-EXPRESSION; STRAINS; AMPD; SUSCEPTIBILITY; HOSPITALS; RESISTOME;
D O I：
10.1128/AAC.03113-15
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Ceftazidime is one of the few cephalosporins with activity against Pseudomonas aeruginosa. Using whole-genome comparative analysis, we set out to determine the prevalent mechanism(s) of resistance to ceftazidime (CAZ) using a set of 181 clinical isolates. These isolates represented various multilocus sequence types that consisted of both ceftazidime-susceptible and -resistant populations. A presumptive resistance mechanism against ceftazidime was identified in 88% of the nonsusceptible isolates using this approach.
引用
收藏
页码：3856 / 3861
页数：6
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