Carbonylation of Alkynes with Different Nucleophiles Catalyzed By Transition Metal Complexes

Carbonylation ( such as hydroformylation, alkoxycarbonylation, hydroxycarbonylation, aminocarbonylation) provides an effective way to synthesize the high value-added carbonyl compounds such as aldehydes ( /alcohols), carboxylic acids, carboxylate esters, amides etc., which is advantageous with high atom economy, excellent selectivities, and mild conditions in comparison to the oxidation. The raw materials involved in carbonylation are comprised of alkenes, alkynes, halohydrocarbons, alcohols etc. Thereinto, with CO or CO-surrogates as carbonyl source, carbonylation of alkyne with different nucleophiles ( such as water, alcohols, amines) over transition-metal catalysts, is one of the most attractive processes to produce the corresponding carbonyl compounds like carboxylic acids, carboxylate esters and amines with 100% atom-economy. The obtained carbonyl compounds are widely applied in the production of pharmaceuticals, foods, and cosmetics as well as organic synthesis like polymerization, Aldol condensation and Micheal addition. In this review, the research status on carbonylation of alkynes in recent decade, in terms of reaction types and carbonyl sources, are summarized and prospected.