Dysmorphic choroid plexuses and hydrocephalus associated with increased nuchal translucency: Early ultrasound markers of de novo thanatophoric dysplasia type II with cloverleaf skull (Kleeblattschaedel)

被引：0

作者：

Tonni, Gabriele ^{[1
]}

Palmisano, Marcella ^{[1
]}

Ginocchi, Vladimiro ^{[2
]}

Ventura, Alessandro ^{[1
]}

Baldi, Maurizia ^{[3
]}

Baffico, Ave Maria ^{[3
]}

机构：

[1] Guastalla Civil Hosp, AUSL Reggio Emilia, Dept Obstet & Gynecol, Guastalla, Italy

[2] Guastalla Civil Hosp, AUSL Reggio Emilia, Radiol Serv, Guastalla, Italy

[3] IRCCS Galliera Hosp, Human Genet Lab, Genoa, Italy

来源：

CONGENITAL ANOMALIES | 2014年 / 54卷 / 04期

关键词：

cynomolgus monkey; finger maze; infant; learning and memory test; thiamazole; SPATIAL MEMORY; FORAGING STRATEGIES; MAZE; ANTAGONISTS; RECEPTOR; TASK; CA3;

D O I：

10.1111/cga.12068

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

A new type of learning and memory test using a finger maze was conducted in infant cynomolgus monkeys that were exposed to thiamazole (2 and 3.5mg/kg per day to pregnant animals orally) during the fetal period (gestational days 120 to 150). We modified Tsuchida's original finger maze test method by reducing the number of trials per day and simplifying the criteria for achievement of training, and we added a long-term memory test. In the memory test, thiamazole-exposed infants required greater time to complete the finger maze test than the control infants although no effect was noted in the training or learning test. The results suggest that an impaired long-term memory could be detected by our modified finger maze test.

引用

页码：228 / 232

页数：5