Rational design of ALK2 small molecule inhibitors for treatment of fibrodysplasia ossificans progressiva (FOP)

被引：0
|
作者：
Luo, Yun [1 ]
Alsamarah, Abdelaziz [2 ]
机构：
[1] Western Univ Hlth Sci, Pharmaceut Sci, Chino Hills, CA USA
[2] Western Univ Hlth Sci, Pharmaceut Sci, Pomona, CA USA
来源：
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 249卷
关键词：
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
331
引用
收藏
页数：1
相关论文
共 50 条
  • [1] Revealing Activation Mechanism of Alk2 Kinase Mutations in Fibrodysplasia Ossificans Progressiva (FOP)
    Alsamarah, Abdelaziz
    Hao, Jijun
    Luo, Yun
    [J]. BIOPHYSICAL JOURNAL, 2016, 110 (03) : 206A - 206A
  • [2] A constitutively activated BMP receptor, ALK2, induces heterotopic bone formation in patients with Fibrodysplasia Ossificans Progressiva (FOP)
    Fukuda, T.
    Kohda, M.
    Kanomata, K.
    Nojima, J.
    Kamizono, J.
    Oda, H.
    Nakayama, K.
    Ohtake, A.
    Miyazono, K.
    Jimi, E.
    Owan, I.
    Okazaki, Y.
    Katagiri, T.
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2007, 22 : S10 - S10
  • [3] A clinical update on BLU-782, an investigational selective ALK2 inhibitor in development for fibrodysplasia ossificans progressiva (FOP)
    Davis, Alison
    Albayya, Faris
    Lobbardi, Riadh
    Palmer, Michael
    Sherwin, Cori Ann
    Green, Sara
    Stevison, Faith
    Kim, Sean
    Wilkie, Gordon
    Kadambi, Vivek
    Dorsch, Marion
    Boral, Andy
    LaBranche, Timothy
    Hurtt, Mark
    Schwabb, Robert
    Stewart, Rachel
    Lyon, Morgan
    Pauplis, Rachel
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2019, 34 : 290 - 290
  • [4] Novel bicyclic pyrazoles as potent ALK2 (R206H) inhibitors for the treatment of fibrodysplasia ossificans progressiva
    Yamamoto, Hirofumi
    Sakai, Naoki
    Ohte, Satoshi
    Sato, Tomohiro
    Sekimata, Katsuhiko
    Matsumoto, Takehisa
    Nakamura, Kana
    Watanabe, Hisami
    Mishima-Tsumagari, Chiemi
    Tanaka, Akiko
    Hashizume, Yoshinobu
    Honma, Teruki
    Katagiri, Takenobu
    Miyazono, Kohei
    Tomoda, Hiroshi
    Shirouzu, Mikako
    Koyama, Hiroo
    [J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2021, 38
  • [5] ALK2: A Therapeutic Target for Fibrodysplasia Ossificans Progressiva and Diffuse Intrinsic Pontine Glioma
    Sekimata, Katsuhiko
    Sato, Tomohiro
    Sakai, Naoki
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2020, 68 (03) : 194 - 200
  • [6] Molecular dynamics study of ALK2 kinase mutations in fibrodysplasia ossificans progressiva disorder
    Luo, Yun
    Alsamarah, Abdelaziz
    Hao, Jijun
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2016, 251
  • [7] Structure of the Bone Morphogenetic Protein Receptor ALK2 and Implications for Fibrodysplasia Ossificans Progressiva
    Chaikuad, Apirat
    Alfano, Ivan
    Kerr, Georgina
    Sanvitale, Caroline E.
    Boergermann, Jan H.
    Triffitt, James T.
    von Delft, Frank
    Knapp, Stefan
    Knaus, Petra
    Bullock, Alex N.
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (44) : 36990 - 36998
  • [8] Development of Macrocycle Kinase Inhibitors for ALK2 Using Fibrodysplasia Ossificans Progressiva-Derived Endothelial Cells
    Sanchez-Duffhues, Gonzalo
    Williams, Eleanor
    Benderitter, Pascal
    Orlova, Valeria
    van Wijhe, Michiel
    de Vinuesa, Amaya Garcia
    Kerr, Georgina
    Caradec, Josselin
    Lodder, Kirsten
    de Boer, Hetty C.
    Goumans, Marie-Jose
    Eekhoff, Elisabeth M. W.
    Morales-Piga, Antonio
    Bachiller-Corral, Javier
    Koolwijk, Pieter
    Bullock, Alex N.
    Hoflack, Jan
    ten Dijke, Peter
    [J]. JBMR PLUS, 2019, 3 (11)
  • [9] Palovarotene approved as first treatment for fibrodysplasia ossificans progressiva (FOP)
    Muhammad Talha
    Mohammad Haris Ali
    [J]. Journal of Rare Diseases, 3 (1):
  • [10] Preclinical Characterization of BCX9250, a Potent Oral Activin receptorlike kinase-2 (ALK2) Inhibitor, for the Treatment of Fibrodysplasia Ossificans Progressiva (FOP)
    Chen, Xilin
    Cheng, Xiaogang
    Kallogg-Yelder, Debra
    Liu, Qinde
    Muppa, Saritha
    Parker, Cynthia
    Raman, Krishnan
    Kotian, Pravin
    Babu, Yarlagadda
    [J]. JOURNAL OF BONE AND MINERAL RESEARCH, 2023, 38 : 96 - 96
12345