Nosocomial sepsis: evaluation of the efficacy of preventive measures in a level-III neonatal intensive care unit

Objective: To evaluate nosocomial infections preventive bundle, implemented in April 2010 in Centro Hospitalar de SAo JoAo (CHSJ) Neonatal Intensive Care Unit (NICU) effectiveness.Methods: Newborns admitted to level-III NICU of CHSJ, between 1 April 2007 and 31 March 2013, with sepsis as discharge diagnosis, were selected and divided into two periods (Period 1 and 2, before and after new preventive bundle introduction). Data from the two periods were compared.Results: Nosocomial sepsis incidence density decreased significantly from 8.6 to 4.8 per 1000 patient days from Period 1 to 2. Nosocomial infections preventive bundle implementation led to a significant decrease in central line-associated bloodstream infections (CLABSI) rates from 14.1 to 10.4 per 1000 catheter days.Conclusions: Nosocomial infections preventive bundle implemented revealed efficient in decreasing the incidence density of nosocomial sepsis. However, CLABSI rates remain high. Physicians should be alert to the need to adhere to strict infection control protocols and institute effective measures for nosocomial infection surveillance.