Nucleoprotein (P40) Binding to 5HT2C Receptors (5HT2CR) is the Key Point in the Pathogenesis of BoDV-1-Infected Hosts

被引：0

作者：

Li, Yuanxin ^{[1
,2
]}

Wang, Lixin ^{[1
,2
]}

Liu, Xueni ^{[1
,2
]}

Huang, Ying ^{[1
,2
]}

Li, Xiaomei ^{[1
,2
]}

He, Hong ^{[2
,3
]}

Xu, Xiaoyan ^{[2
]}

Guo, Yujie ^{[2
]}

Li, Qi ^{[4
]}

Zhu, Dan ^{[5
]}

Wang, Xingyu ^{[1
,2
]}

Wang, Haiyang ^{[2
]}

Li, Wenwen ^{[1
,2
]}

Li, Dan ^{[1
,2
]}

Xie, Peng ^{[2
]}

机构：

[1] Chongqing Med Univ, Dept Pathol, Fac Basic Med, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China

[2] Chongqing Med Univ, Affiliated Hosp 1, NHC Key Lab Diag & Treatment Brain Funct Dis, 1 Yixueyuan Rd, Chongqing 400016, Peoples R China

[3] Chongqing Med Univ, Affiliated Hosp 1, Branch 1, Dept Neurol, Chongqing 400016, Peoples R China

[4] Chongqing Med Univ, Affiliated Hosp 1, Dept Neurol, Chongqing 400016, Peoples R China

[5] Chongqing Med Univ, Affiliated Hosp 1, Dept Phys Examinat, 1 Youyi Rd, Chongqing 400016, Peoples R China

来源：

NEUROCHEMICAL RESEARCH | 2021年 / 46卷 / 09期

关键词：

Borna disease virus 1; Interactome; P40; 5HT2CR; Neuropsychiatric diseases; BORNA-DISEASE-VIRUS; IN-VIVO; SB; 200646A; INFECTION; ANTAGONIST; MODELS; ADULT; RATS; EPIDEMIOLOGY; BEHAVIOR;

D O I：

10.1007/s11064-021-03385-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nucleoprotein (P40) is one of the most important proteins of Borna disease virus 1 (BoDV-1), but which proteins it would bind to in the pathogenesis of BoDV-1-infected hosts is unknown. We used lentivirus LV5-P40 overexpressing P40 to infect primary hippocampal neurons and characterized the interactome of P40 with co-immunoprecipitation (Co-IP) followed by mass spectrometry (MS) analysis. These interacting protein partners revealed the pathogenesis of BoDV-1-infected hosts. We also show for the first time that P40 interacts with 5HT2CR in rat neurons, which may be the molecular basis leading to neuropsychiatric diseases such as anxiety disorders and behavioral abnormalities after BoDV-1 infection of hosts.

引用

页码：2427 / 2438

页数：12

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