Lack of transgenerational effects of ionizing radiation exposure from the Chernobyl accident

被引：64

作者：

Yeager, Meredith ^{[1
,2
]}

Machiela, Mitchell J. ^{[1
]}

Kothiya, Prachi ^{[1
,3
]}

Dean, Michael ^{[1
,2
]}

Bodelon, Clara ^{[1
]}

Suman, Shalabh ^{[1
,2
]}

Wang, Mingyi ^{[1
,2
]}

Mirabello, Lisa ^{[1
]}

Nelson, Chase W. ^{[4
,5
]}

Zhou, Weiyin ^{[1
,2
]}

Palmer, Cameron ^{[1
,2
]}

Ballew, Bari ^{[1
,2
]}

Colli, Leandro M. ^{[1
,6
]}

Freedman, Neal D. ^{[1
]}

Dagnall, Casey ^{[1
,2
]}

Hutchinson, Amy ^{[1
,2
]}

Vij, Vibha ^{[1
]}

Maruvka, Yosi ^{[7
,8
]}

Hatch, Maureen ^{[1
]}

Illienko, Iryna ^{[9
]}

Belayev, Yuri ^{[9
]}

Nakamura, Nori ^{[10
]}

Chumak, Vadim ^{[9
]}

Bakhanova, Elena ^{[9
]}

Belyi, David ^{[9
]}

Kryuchkov, Victor ^{[11
]}

Golovanov, Ivan ^{[11
]}

Gudzenko, Natalia ^{[9
]}

Cahoon, Elizabeth K. ^{[1
]}

Albert, Paul ^{[1
]}

Drozdovitch, Vladimir ^{[1
]}

Little, Mark P. ^{[1
]}

Mabuchi, Kiyohiko ^{[1
]}

Stewart, Chip ^{[7
]}

Getz, Gad ^{[7
,8
,12
,13
]}

Bazyka, Dimitry ^{[9
]}

de Gonzalez, Amy Berrington ^{[1
]}

Chanock, Stephen J. ^{[1
]}

机构：

[1] NCI, Div Canc Epidemiol & Genet, Rockville, MD 20892 USA

[2] Frederick Natl Lab Canc Res, Canc Genom Res Lab, Frederick, MD 21701 USA

[3] SymbioSeg LLC, Arlington, VA 20148 USA

[4] Acad Sinica, Biodivers Res Ctr, Taipei 11529, Taiwan

[5] Amer Museum Nat Hist, Inst Comparat Genom, New York, NY 10024 USA

[6] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Med Imaging Hematol & Oncol, BR-14049900 Ribeirao Preto, SP, Brazil

[7] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA

[8] Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02114 USA

[9] Natl Res Ctr Radiat Med, 53 Yu Illienka St, UA-04050 Kiev, Ukraine

[10] Radiat Effects Res Fdn, Dept Mol Biosci, Minami Ku, 5-2 Hijiyama Pk, Hiroshima 7320815, Japan

[11] Bumasyan Fed Med & Biophys Ctr, 46 Zhivopisnaya St, Moscow 123182, Russia

[12] Massachusetts Gen Hosp, Dept Pathol, Boston, MA 02114 USA

[13] Harvard Med Sch, Boston, MA 02115 USA

来源：

SCIENCE | 2021年 / 372卷 / 6543期

关键词：

DE-NOVO MUTATIONS; CLEANUP WORKERS; MATERNAL AGE; GERMLINE; CHILDREN; RATES; NUCLEOTIDE; PATTERNS; DAMAGE; LOCI;

D O I：

10.1126/science.abg2365

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Effects of radiation exposure from the Chernobyl nuclear accident remain a topic of interest. We investigated germline de novo mutations (DNMs) in children born to parents employed as cleanup workers or exposed to occupational and environmental ionizing radiation after the accident. Whole-genome sequencing of 130 children (born 1987-2002) and their parents did not reveal an increase in the rates, distributions, or types of DNMs relative to the results of previous studies. We find no elevation in total DNMs, regardless of cumulative preconception gonadal paternal [mean = 365 milligrays (mGy), range = 0 to 4080 mGy] or maternal (mean = 19 mGy, range = 0 to 550 mGy) exposure to ionizing radiation. Thus, we conclude that, over this exposure range, evidence is lacking for a substantial effect on germline DNMs in humans, suggesting minimal impact from transgenerational genetic effects.

引用

页码：725 / +

页数：40

共 50 条

[1] HUMAN EFFECTS FOLLOWING EXPOSURE TO IONIZING-RADIATION - THE ACCIDENT AT CHERNOBYL - THE DATA FROM HIROSHIMA AND NAGASAKI
JOHNSON, ML
ARCHIVES OF DERMATOLOGY, 1986, 122 (12) : 1380 - 1382
[2] A transgenerational mutational signature from ionizing radiation exposure
Brand, Fabian
Klinkhammer, Hannah
Knaus, Alexej
Holtgrewe, Manuel
Beule, Dieter
Krawitz, Peter
EUROPEAN JOURNAL OF HUMAN GENETICS, 2024, 32 : 597 - 597
[3] Psychophysiological pattern of acute prenatal exposure to ionizing radiation as a result of the Chernobyl accident
Loganovskaja, TK
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY, 2004, 54 (1-2) : 95 - 96
[4] Leukemia after radiation exposure from the Chernobyl accident
Howe, Geoffrey R.
Zablotska, Lydia B.
RADIATION RESEARCH, 2007, 167 (03) : 340 - 341
[5] BRAIN DAMAGE FOLOWING EXPOSURE TO LOW DOSES OF IONIZING RADIATION AS A RESULT OF THE CHERNOBYL ACCIDENT
Loganovsky, Konstantin
CLINICAL NEUROPSYCHIATRY, 2012, 9 (05): : 203 - 204
[6] Ionizing radiation effects on soil biota: Application of lessons learned from Chernobyl accident for radioecological monitoring
Zaitsev, Andrei S.
Gongalsky, Konstantin B.
Nakamori, Taizo
Kaneko, Nobutdro
PEDOBIOLOGIA, 2014, 57 (01) : 5 - 14
[7] Radiation Exposure to the Thyroid After the Chernobyl Accident
Drozdovitch, Vladimir
FRONTIERS IN ENDOCRINOLOGY, 2021, 11
[8] Ionizing radiation from the Chernobyl accident results in abnormal cytokine gene expression in vivo
Dainiak, N
Karkanitsa, L
Ostapenko, V
Kruchinsky, N
Shablovsky, G
Hamid, O
EXPERIMENTAL HEMATOLOGY, 1997, 25 (08) : 137 - 137
[9] RADIATION EXPOSURE FROM CHERNOBYL NUCLEAR ACCIDENT IN EASTERN-EUROPE
SABAU, MN
MEDICAL PHYSICS, 1987, 14 (04) : 712 - 712
[10] Strong effects of ionizing radiation from Chernobyl on mutation rates
Moller, Anders Pape
Mousseau, Timothy A.
SCIENTIFIC REPORTS, 2015, 5

← 1 2 3 4 5 →