Comprehensive Clinicopathologic and Updated Immunohistochemical Characterization of Primary Ovarian Mucinous Carcinoma

被引：32
|
作者：
Bassiouny, Dina [1 ,2 ,3 ]
Ismiil, Nadia [1 ,2 ]
Dube, Valerie [1 ,2 ]
Han, Guangming [1 ,2 ]
Cesari, Matthew [1 ,2 ]
Lu, Fang-I [1 ,2 ]
Slodkowska, Elzbieta [1 ,2 ]
Parra-Herran, Carlos [1 ,2 ]
Chiu, Hak Fai [1 ]
Naeim, Magda [1 ]
Li, Nim [1 ]
Khalifa, Mahmoud [1 ,2 ]
Nofech-Mozes, Sharon [1 ,2 ]
机构：
[1] Sunnybrook Hlth Sci Ctr, Toronto, ON, Canada
[2] Univ Toronto, Toronto, ON, Canada
[3] Mansoura Univ, Mansoura, Egypt
来源：
INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY | 2018年 / 26卷 / 04期
关键词：
ovarian cancer; mucinous; immunohistochemistry; SATB2; HER2; PAX8; napsin A; HNFlb; LYMPH-NODE METASTASIS; CLEAR-CELL CARCINOMA; DIFFERENTIAL-DIAGNOSIS; ENDOMETRIOID CARCINOMA; TUMOR-SUPPRESSOR; SATB2; EXPRESSION; LYNCH SYNDROME; BREAST-CANCER; ARID1A; ADENOCARCINOMA;
D O I：
10.1177/1066896917752861
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
The distinction of primary mucinous ovarian carcinoma (PMOC) from other primaries or secondaries is essential for selecting therapeutic options and prognostication. We aimed to characterize the immunohistochemical profile of 36 PMOCs using an extended immunohistochemical panel, with clinicopathologic features and outcome. PAX8 was negative in 30 (83.3%), and SATB2 was negative in 32/35. HNF1B, AMACR, and napsin-A were detected in 33 (91.7%), 35 (97.2%), and 0 (0%), respectively. MMR proteins and ARID1A were retained in 100%; PTEN was lost in 4 (11.1%). P53 was aberrant in 10 (27.8%); none overexpressed p16. HER2 was positive in 6/35 (17.1%). Most PMOCs had a favorable outcome. However, recurrence is usually fatal. The typical tumor profile was CK7+, CK20+/-, CDX2+/-, PAX8-, ER-, PgR-, and SATB2-. HER2 positivity suggests a possible target for therapy in advanced disease.
引用
收藏
页码：306 / 317
页数：12
相关论文
共 50 条
  • [1] Comprehensive Genomic Characterization of Primary Ovarian Mucinous Carcinoma
    Parra-Herran, Carlos
    Nofech-Mozes, Sharon
    Uzunovic, Jasmina
    Lamaze, Fabien
    Lungu, Ilinca
    Ptak, Carolyn
    Lam, Bernard
    Krzyzanowski, Paul
    Busca, Aurelia
    Bassiouny, Dina
    Bayani, Jane
    Awadalla, Philip
    Bartlett, John
    MODERN PATHOLOGY, 2020, 33 (SUPPL 2) : 1116 - 1117
  • [2] Comprehensive Genomic Characterization of Primary Ovarian Mucinous Carcinoma
    Parra-Herran, Carlos
    Nofech-Mozes, Sharon
    Uzunovic, Jasmina
    Lamaze, Fabien
    Lungu, Ilinca
    Ptak, Carolyn
    Lam, Bernard
    Krzyzanowski, Paul
    Busca, Aurelia
    Bassiouny, Dina
    Bayani, Jane
    Awadalla, Philip
    Bartlett, John
    LABORATORY INVESTIGATION, 2020, 100 (SUPPL 1) : 1116 - 1117
  • [3] Primary Mucinous Carcinoma of the Eyelid A Clinicopathologic and Immunohistochemical Study of 4 Cases and an Update on Recurrence Rates
    Papalas, John A.
    Proia, Alan D.
    ARCHIVES OF OPHTHALMOLOGY, 2010, 128 (09) : 1160 - 1165
  • [4] Comprehensive genomic profiling of mucinous ovarian carcinoma with comparisons to mucinous colorectal carcinoma
    Jones, N. L.
    Arguello, D.
    Holloway, R. W.
    Herzog, T. J.
    ElNaggar, A. C.
    Winer, I.
    Krivak, T. C.
    Mantia-Smaldone, G. M.
    Galvan-Turner, V.
    Brown, J.
    GYNECOLOGIC ONCOLOGY, 2019, 154 : 63 - 63
  • [5] Clinicopathologic Correlation of Mucinous Differentiation in Primary Ovarian Endometrioid Adenocarcinoma
    Jagannathan, Geetha
    Goldberg, Allison
    Guarente, Juliana
    DeCotiis, Dan
    Rosenblum, Norman
    Chan, Joanna
    AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2018, 150 : S31 - S32
  • [6] Molecular characterization of mucinous ovarian carcinoma
    Levine, Douglas A.
    Schlappe, Brooke
    CLINICAL CANCER RESEARCH, 2016, 22
  • [7] Comparison of Immunohistochemistry to a Clinicopathologic Classifier in the Diagnosis of Primary Mucinous Ovarian Tumor
    Varshney, Neha
    Farhat, Ilham
    Bellizzi, Andrew
    MODERN PATHOLOGY, 2020, 33 (SUPPL 2) : 833 - 834
  • [8] Comparison of Immunohistochemistry to a Clinicopathologic Classifier in the Diagnosis of Primary Mucinous Ovarian Tumor
    Varshney, Neha
    Farhat, Ilham
    Bellizzi, Andrew
    LABORATORY INVESTIGATION, 2020, 100 (SUPPL 1) : 833 - 834
  • [9] Clinicopathologic and immunohistochemical profile of ovarian metastases from colorectal carcinoma
    Kir, Gozde
    Gurbuz, Ayse
    Karateke, Ates
    Kir, Mustafa
    WORLD JOURNAL OF GASTROINTESTINAL SURGERY, 2010, 2 (04): : 109 - 116
  • [10] NUT Carcinoma: A Clinicopathologic and Comprehensive Immunohistochemical Analysis of 54 Cases
    Farooq, Ayesha
    Lo, Ying-Chun
    MODERN PATHOLOGY, 2022, 35 (SUPPL 2) : 1305 - 1305
12345