Phosphoinositide metabolism and Ca2+ oscillation

被引：0
|
作者：
Tkachuk, VA [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Sch Basic Med, Dept Biol & Med Chem, Moscow 119899, Russia
来源：
BIOCHEMISTRY-MOSCOW | 1998年 / 63卷 / 01期
关键词：
phosphoinositide metabolism; calcium; hormones; growth factors;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The main pathways of hydrolysis and synthesis of phosphoinositides, metabolism of inositol phosphates and their role in animal and human cells are reviewed, Mechanisms of regulation of phospholipase C and other key enzymes of phosphoinositide metabolism by hormones and growth factors are discussed. The mechanisms of regulation of metabolism and cellular activity by second messengers formed during activation of phosphoinositide hydrolysis are considered. Special attention is given to the regulation of cytoplasmic Ca2+ level by inositol phosphates. The review summarizes data on formation and possible biological role of inositol phosphates and phosphoinositides containing phosphate at position 3. The role of phosphoinositides in the interaction of cellular membranes with proteins of the cytoskeleton is considered.
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页码：38 / 46
页数：9
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